About: Cellular Antiviral Factors that Target Particle Infectivity of HIV-1

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cellular Antiviral Factors that Target Particle Infectivity of HIV-1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cellular Antiviral Factors that Target Particle Infectivity of HIV-1
Creator	Goffinet, Christine
source	Medline; PMC
abstract	Background: In the past decade, the identification and characterization of antiviral genes with the ability to interfere with virus replication has established cell-intrinsic innate immunity as a third line of antiviral defense in addition to adaptive and classical innate immunity. Understanding how cellular factors have evolved to inhibit HIV-1 reveals particularly vulnerable points of the viral replication cycle. Many, but not all, antiviral proteins share type I interferon-upregulated expression and sensitivity to viral counteraction or evasion measures. Whereas well-established restriction factors interfere with early post-entry steps and release of HIV-1, recent research has revealed a diverse set of proteins that reduce the infectious quality of released particles using individual, to date poorly understood modes of action. These include induction of paucity of mature glycoproteins in nascent virions or self-incorporation into the virus particle, resulting in poor infectiousness of the virion and impaired spread of the infection. Conclusion: A better understanding of these newly discovered antiviral factors may open new avenues towards the design of drugs that repress the spread of viruses whose genomes have already integrated.
has issue date	2016-05-01(xsd:dateTime)
bibo:doi	10.2174/1570162x14666151216145521
bibo:pmid	26674651
has license	cc-by-nc
sha1sum (hex)	27ee5b4647398fd11e7044166a9d68aca391ebcf
schema:url	https://doi.org/10.2174/1570162x14666151216145521
resource representing a document's title	Cellular Antiviral Factors that Target Particle Infectivity of HIV-1
has PubMed Central identifier	PMC5403965
has PubMed identifier	26674651
schema:publication	Curr HIV Res
resource representing a document's body	covid:27ee5b4647398fd11e7044166a9d68aca391ebcf#body_text
is schema:about of	named entity 'reduce' named entity 'type I' named entity 'virions' named entity 'addition' named entity 'innate' named entity 'released' named entity 'Infectivity' named entity 'Target' named entity 'Antiviral' named entity 'mature' named entity 'viral replication' named entity 'sensitivity' named entity 'genes' named entity 'interfere' named entity 'expression' named entity 'HIV-1' named entity 'virus particle' named entity 'viral replication cycle' named entity 'upregulated' named entity 'set of proteins' named entity 'cell surface receptors' named entity 'infectivity' named entity 'protease' named entity 'tetherin' named entity 'viruses' named entity 'primate' named entity 'virus' named entity 'antiviral' named entity 'HIV-1' named entity 'HIV-1' named entity 'highly vulnerable' named entity 'antiviral' named entity 'mode of action' named entity 'Vesicular Stomatitis virus' named entity 'coreceptor' named entity 'HIV-1 infection' named entity 'virus' named entity 'chemokine' named entity 'HIV-1' named entity 'Co-IP' named entity 'coronaviruses' named entity 'HIV-1' named entity 'gp120' named entity 'enveloped viruses' named entity 'HIV-1' named entity 'virion' named entity 'processivity' named entity 'cell signaling' named entity 'viruses' named entity 'transmembrane proteins' named entity 'HIV-1' named entity 'virally' named entity 'protein' named entity 'virus' named entity 'viral membrane' named entity 'HIV-1' named entity 'effector' named entity 'SAMHD1' named entity 'transcriptional activity' named entity 'cell type' named entity 'plasma membrane' named entity 'serum' named entity 'HIV-1 infection' named entity 'IFITM3' named entity 'CD225' named entity 'protease' named entity 'protein expression' named entity 'virus' named entity 'post-transcriptional' named entity 'virus' named entity 'protein' named entity 'subcellular localization' named entity 'cell surface' named entity 'HIV-1' named entity 'antiviral activity' named entity 'protein' named entity 'virion' named entity 'protein' named entity 'trimers' named entity 'gp41' named entity 'T-cells'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software