About: Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

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About: Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection
Creator	Bader, Michael Beck, Sebastian Correspondence, Gabriel Hartmann, Enno Stanelle-Bertram, Stephanie Thiele, Swantje
source	Elsevier; Medline; PMC
abstract	Importin-α adaptor proteins orchestrate dynamic nuclear transport processes involved in cellular homeostasis. Here, we show that importin-α3, one of the main NF-κB transporters, is the most abundantly expressed classical nuclear transport factor in the mammalian respiratory tract. Importin-α3 promoter activity is regulated by TNF-α-induced NF-κB in a concentration-dependent manner. High-level TNF-α-inducing highly pathogenic avian influenza A viruses (HPAIVs) isolated from fatal human cases harboring human-type polymerase signatures (PB2 627K, 701N) significantly downregulate importin-α3 mRNA expression in primary lung cells. Importin-α3 depletion is restored upon back-mutating the HPAIV polymerase into an avian-type signature (PB2 627E, 701D) that can no longer induce high TNF-α levels. Importin-α3-deficient mice show reduced NF-κB-activated antiviral gene expression and increased influenza lethality. Thus, importin-α3 plays a key role in antiviral immunity against influenza. Lifting the bottleneck in importin-α3 availability in the lung might provide a new strategy to combat respiratory virus infections.
has issue date	2020-04-21(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2020.107549
bibo:pmid	32320654
has license	no-cc
sha1sum (hex)	2841462a4f0639168831b839a6c4dc1f3b082bdd
schema:url	https://doi.org/10.1016/j.celrep.2020.107549
resource representing a document's title	Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection
has PubMed Central identifier	PMC7172908
has PubMed identifier	32320654
schema:publication	Cell Rep
resource representing a document's body	covid:2841462a4f0639168831b839a6c4dc1f3b082bdd#body_text
is schema:about of	named entity 'NUCLEAR' named entity 'NF-kB' named entity 'Importin' named entity 'Lung' named entity 'Influenza A Virus' named entity 'importin-a' named entity 'importin' named entity 'importin' named entity 'NF-kB' named entity 'murine' named entity 'luciferase' named entity 'RNA' named entity 'isoforms' named entity 'Germany' named entity 'embryos' named entity 'IFNA' named entity 'importin' named entity 'gene' named entity 'gene' named entity 'trachea' named entity 'importin' named entity 'gradient' named entity 'primers' named entity 'homologous recombination' named entity 'gene' named entity 'chicken' named entity 'epithelial cells' named entity 'Mouse embryonic fibroblasts' named entity 'NF-kB' named entity 'Importin' named entity 'CFs' named entity 'importin' named entity 'importin' named entity 'importin' named entity 'importin-a' named entity 'importin' named entity 'mice' named entity 'importin' named entity 'nucleus' named entity 'TNF-a' named entity 'environmental stress' named entity 'nuclear import' named entity 'antiviral' named entity 'recombinant' named entity 'Biopsy' named entity 'protein expression' named entity 'importin' named entity 'protein transport' named entity 'antibodies' named entity 'nuclear localization' named entity 'TNFa' named entity 'importin-a' named entity 'importin' named entity 'anti-FLAG' named entity 'IRF-3' named entity 'zoonotic transmission' named entity 'importin-a' named entity 'disease outcome' named entity 'mRNA' named entity 'importin' named entity 'protein' named entity 'infection' named entity 'QIAGEN' named entity 'nuclear import' named entity 'physical appearance' named entity 'polymerase' named entity 'SC35' named entity 'mRNA' named entity 'cytokines' named entity 'GraphPad Prism' named entity 'immune responses' named entity 'isoforms' named entity 'TNF-a' named entity 'cytokines' named entity 'protein' named entity 'virus'

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