About: Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates
Creator	Kuiken, Thijs Osterhaus, Albert Andeweg, Arno Haagmans, Bart De Lang, Anna Eijkemans, Marinus Leijten, Lonneke Smits, Saskia Van Amerongen, Geert Van Den Brand, Judith Van Ijcken, Wilfred
Source	Medline; PMC
abstract	The emergence of viral respiratory pathogens with pandemic potential, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and influenza A H5N1, urges the need for deciphering their pathogenesis to develop new intervention strategies. SARS-CoV infection causes acute lung injury (ALI) that may develop into life-threatening acute respiratory distress syndrome (ARDS) with advanced age correlating positively with adverse disease outcome. The molecular pathways, however, that cause virus-induced ALI/ARDS in aged individuals are ill-defined. Here, we show that SARS-CoV-infected aged macaques develop more severe pathology than young adult animals, even though viral replication levels are similar. Comprehensive genomic analyses indicate that aged macaques have a stronger host response to virus infection than young adult macaques, with an increase in differential expression of genes associated with inflammation, with NF-κB as central player, whereas expression of type I interferon (IFN)-β is reduced. Therapeutic treatment of SARS-CoV-infected aged macaques with type I IFN reduces pathology and diminishes pro-inflammatory gene expression, including interleukin-8 (IL-8) levels, without affecting virus replication in the lungs. Thus, ALI in SARS-CoV-infected aged macaques developed as a result of an exacerbated innate host response. The anti-inflammatory action of type I IFN reveals a potential intervention strategy for virus-induced ALI.
has issue date	2010-02-05(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1000756
bibo:pmid	20140198
has license	cc-by
sha1sum (hex)	284790100b67133f3228466016a8f98ad096e24d
schema:url	https://doi.org/10.1371/journal.ppat.1000756
resource representing a document's title	Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates
has PubMed Central identifier	PMC2816697
has PubMed identifier	20140198
schema:publication	PLoS Pathog
resource representing a document's body	covid:284790100b67133f3228466016a8f98ad096e24d#body_text
is schema:about of	named entity 'differential' named entity 'virus' named entity 'macaques' named entity 'potential' named entity 'adverse' named entity 'macaques' named entity 'ALI' named entity 'EXACERBATED' named entity 'INFLAMMATORY' named entity 'H5N1' named entity 'EMERGENCE' named entity 'VIRAL REPLICATION' named entity 'THE LUNGS' named entity 'THEIR' named entity 'INTERLEUKIN-8 ' named entity 'REVEALS' named entity 'CENTRAL' named entity 'EXPRESSION' named entity 'VIRUS' named entity 'VIRUS INFECTION' named entity 'HAVE' named entity 'PANDEMIC' named entity 'ADVANCED AGE' named entity 'YOUNG ADULT' named entity 'POTENTIAL' named entity 'INCREASE' named entity 'INTERVENTION' named entity 'GENES' named entity 'CAUSE' named entity 'LIFE' named entity 'AGED' named entity 'INFLAMMATION' named entity 'MACAQUES' named entity 'ANTI-INFLAMMATORY ACTION' named entity 'COMPREHENSIVE' named entity 'WITH TYPE' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'GENOMIC' named entity 'ASSOCIATED WITH' named entity 'NF-KB' named entity 'PATHOGENESIS' named entity 'TYPE I INTERFERON' named entity 'THERAPEUTIC' named entity 'ILL-DEFINED' named entity 'INDIVIDUALS' named entity 'INDUCED' named entity 'AS A RESULT OF' named entity 'REDUCED' named entity 'HOST RESPONSE' named entity 'TYPE I' named entity 'HOST RESPONSE' named entity 'ACUTE LUNG INJURY' named entity 'INTERFERON ' named entity 'SARS-COV' named entity 'GENE EXPRESSION' named entity 'INFECTED' named entity 'INTERVENTION STRATEGIES' named entity 'STRATEGY' named entity 'INCLUDING' named entity 'NON-' named entity 'AGED' named entity 'HUMAN' named entity 'DISEASE OUTCOME' named entity 'ANIMALS' named entity 'EXACERBATED' named entity 'AFFECTING' named entity 'SARS-COV INFECTION' named entity 'LEVELS' named entity 'RESPONSE TO VIRUS' named entity 'IFN' named entity 'NEED FOR'

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