About: Quantal formation of lentiviruses in cells: segregation of viral glycoproteins to lipid rafts that associate individually with HIV-1 Capsids

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About: Quantal formation of lentiviruses in cells: segregation of viral glycoproteins to lipid rafts that associate individually with HIV-1 Capsids Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Quantal formation of lentiviruses in cells: segregation of viral glycoproteins to lipid rafts that associate individually with HIV-1 Capsids
Creator	Ganesh, Lakshmanan Leung, Kwanyee Schwartz, Owen Kabat, Juraj Kim, Jae-Ouk Nabel, Gary
Source	Elsevier; Medline; PMC
abstract	The viral ribonucleoprotein complex of human immunodeficiency virus-1 (HIV-1) associates with the viral Envelope (Env) to form infectious virions. While Env and Gag are known to migrate to lipid microdomains, their stoichiometry and specificity of interaction is not known. Here, we analyze the association of different viral glycoproteins, HIV Env and Ebola GP, with HIV-1 Gag protein co-expressed in the same cell. Though these two viral spikes were both expressed, each associated independently with Gag and gave rise to two distinct virion populations, each with a spike of a single type. Confocal imaging demonstrated that HIV Env(89.6) and Ebola GP localized to distinct lipid raft microdomains within the same cell, where each associated with distinct Gag particles. Similar Env localization was observed in HIV-infected T cells, where ~14 percent of Env was associated with Gag during productive infection. Together, these data suggest that a single Gag complex associates “quantally” with an individual lipid raft microdomain to assemble functional virions during infection.
has issue date	2008-05-01(xsd:dateTime)
bibo:doi	10.1016/j.chom.2008.04.004
bibo:pmid	18474355
has license	green-oa
sha1sum (hex)	286ea79fd5d6c74fc0d6205ffe440abbc42428b7
schema:url	https://doi.org/10.1016/j.chom.2008.04.004
resource representing a document's title	Quantal formation of lentiviruses in cells: segregation of viral glycoproteins to lipid rafts that associate individually with HIV-1 Capsids
has PubMed Central identifier	PMC2998762
has PubMed identifier	18474355
schema:publication	Cell Host & Microbe
resource representing a document's body	covid:286ea79fd5d6c74fc0d6205ffe440abbc42428b7#body_text
is schema:about of	named entity 'ASSOCIATE' named entity 'infection' named entity 'localized' named entity 'segregation' named entity 'SUGGEST' named entity 'POPULATIONS' named entity 'THESE' named entity 'OBSERVED' named entity 'CELL' named entity 'GAG' named entity 'PERCENT' named entity 'SINGLE' named entity 'FUNCTIONAL' named entity 'DATA' named entity 'INDIVIDUAL' named entity 'HIV' named entity 'HERE' named entity 'LOCALIZED' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'TO FORM' named entity 'STOICHIOMETRY' named entity 'EXPRESSED' named entity 'SIMILAR' named entity 'SPECIFICITY' named entity 'GAG PROTEIN' named entity 'COMPLEX' named entity 'GLYCOPROTEINS' named entity 'VIRIONS' named entity 'GLYCOPROTEINS' named entity 'GAVE' named entity 'SPIKE' named entity 'KNOWN' named entity 'RISE' named entity 'PARTICLES' named entity 'HIV-1' named entity 'MIGRATE' named entity 'VIRION' named entity 'INFECTED' named entity 'TYPE' named entity 'WHERE' named entity 'DISTINCT' named entity 'LIPID' named entity 'CONFOCAL IMAGING' named entity 'LIPID RAFT' named entity 'ASSOCIATES' named entity 'INFECTIOUS' named entity 'RIBONUCLEOPROTEIN COMPLEX' named entity 'SEGREGATION' named entity 'ASSOCIATED' named entity 'LOCALIZATION' named entity 'ENV' named entity 'ASSOCIATION' named entity 'CAPSIDS' named entity 'LIPID RAFTS' named entity 'LENTIVIRUSES' named entity 'HIV-1' named entity 'FORMATION' named entity 'THEIR' named entity 'SPIKES' named entity 'TO ASSEMBLE' named entity 'ASSOCIATED WITH' named entity 'VIRAL' named entity 'INTERACTION' named entity 'DEMONSTRATED' named entity 'T CELLS' named entity 'PROTEIN ' named entity 'DIFFERENT' named entity 'VIRAL ENVELOPE' named entity 'PRODUCTIVE' named entity 'VIRAL' named entity 'CELLS' named entity 'NOT KNOWN' named entity 'EBOLA' named entity 'INFECTION' covid:arg/286ea79fd5d6c74fc0d6205ffe440abbc42428b7 named entity 'localization'

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