About: Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

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About: Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates
Creator	Gale, Michael Feldmann, Heinz Veesler, David Walls, Alexandra Carter, Darrick Reed, Steven Hemann, Emily Fuller, Deborah Hawman, David Archer, Jacob Berglund, Peter Draves, Kevin Duthie, Malcolm Erasmus, Jesse Fuller, Jim Guerriero, Kathryn Khandhar, Amit Leventhal, Shanna Lewis, Thomas Murapa, Patience O'connor, Megan Randall, Samantha
source	BioRxiv; Medline
abstract	The ongoing COVID-19 pandemic, caused by infection with SARS-CoV-2, is having a dramatic and deleterious impact on health services and the global economy. Grim public health statistics highlight the need for vaccines that can rapidly confer protection after a single dose and be manufactured using components suitable for scale-up and efficient distribution. In response, we have rapidly developed repRNA-CoV2S, a stable and highly immunogenic vaccine candidate comprised of an RNA replicon formulated with a novel Lipid InOrganic Nanoparticle (LION) designed to enhance vaccine stability, delivery and immunogenicity. We show that intramuscular injection of LION/repRNA-CoV2S elicits robust anti-SARS-CoV-2 spike protein IgG antibody isotypes indicative of a Type 1 T helper response as well as potent T cell responses in mice. Importantly, a single-dose administration in nonhuman primates elicited antibody responses that potently neutralized SARS-CoV-2. These data support further development of LION/repRNA-CoV2S as a vaccine candidate for prophylactic protection from SARS-CoV-2 infection.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.1101/2020.05.28.121640
bibo:pmid	32511417
has license	biorxiv
sha1sum (hex)	2893afcb9dd20835e62e422a2db8f524dc89ae2e
schema:url	https://doi.org/10.1101/2020.05.28.121640
resource representing a document's title	Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates
has PubMed identifier	32511417
schema:publication	bioRxiv
resource representing a document's body	covid:2893afcb9dd20835e62e422a2db8f524dc89ae2e#body_text
is schema:about of	named entity 'Coronavirus' named entity 'RBD' named entity 'SARS-CoV-2' named entity 'protein' named entity 'Protection' named entity 'response' named entity 'Severe acute respiratory syndrome coronavirus' named entity 'caused' named entity 'protein' named entity 'stable' named entity 'impact' named entity 'neutralizing antibodies' named entity 'rapidly' named entity 'neutralizing' named entity 'replicon' named entity 'COVID-19' named entity 'genome' named entity 'envelope' named entity 'December' named entity 'cell types' named entity 'inducing' named entity 'RNA' named entity 'converting' named entity 'protein' named entity 'Disease' named entity 'nucleocapsid' named entity 'structural proteins' named entity 'antibodies' named entity 'membrane' named entity 'MERS' named entity 'vaccines' named entity 'RBD' named entity 'vaccine' named entity 'enzyme' named entity 'immunogenicity' named entity 'Middle East respiratory syndrome' named entity 'Coronavirus Disease 2019' named entity 'COVID' named entity 'angiotensin' named entity 'coronaviruses' named entity 'Lipid' named entity 'worldwide pandemic' named entity 'cell types' named entity 'infection' named entity 'SARS-CoV' named entity 'neutralizing antibodies' named entity 'emerged' named entity 'vaccine' named entity 'effective' named entity 'COVID' named entity 'mice' named entity 'Proteinase' named entity 'immunization' named entity 'epitope tag' named entity 'nitrocellulose' named entity 'Gel electrophoresis' named entity 'immunization' named entity 'prophylactic' named entity 'VWR International' named entity 'SARS-CoV' named entity 'Nanoparticle'

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