About: Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis
Creator	Abeel, Thomas Dolganov, Gregory Galagan, James Iacobelli-Martinez, Milena Koehrsen, Mike Peterson, Matthew Raman, Sahadevan Regev, Aviv Riley, Robert Sisk, Peter Stolte, Christian Wapinski, Ilan Weiner, Brian White, Jared Zucker, Jeremy Schoolnik, Gary Kidd, Matthew Maer, Andreia Manson Mcguire, Abigail Park, Sang Yamamoto, Robert
Source	PMC
abstract	BACKGROUND: The sequence of the pathogen Mycobacterium tuberculosis (Mtb) strain H37Rv has been available for over a decade, but the biology of the pathogen remains poorly understood. Genome sequences from other Mtb strains and closely related bacteria present an opportunity to apply the power of comparative genomics to understand the evolution of Mtb pathogenesis. We conducted a comparative analysis using 31 genomes from the Tuberculosis Database (TBDB.org), including 8 strains of Mtb and M. bovis, 11 additional Mycobacteria, 4 Corynebacteria, 2 Streptomyces, Rhodococcus jostii RHA1, Nocardia farcinia, Acidothermus cellulolyticus, Rhodobacter sphaeroides, Propionibacterium acnes, and Bifidobacterium longum. RESULTS: Our results highlight the functional importance of lipid metabolism and its regulation, and reveal variation between the evolutionary profiles of genes implicated in saturated and unsaturated fatty acid metabolism. It also suggests that DNA repair and molybdopterin cofactors are important in pathogenic Mycobacteria. By analyzing sequence conservation and gene expression data, we identify nearly 400 conserved noncoding regions. These include 37 predicted promoter regulatory motifs, of which 14 correspond to previously validated motifs, as well as 50 potential noncoding RNAs, of which we experimentally confirm the expression of four. CONCLUSIONS: Our analysis of protein evolution highlights gene families that are associated with the adaptation of environmental Mycobacteria to obligate pathogenesis. These families include fatty acid metabolism, DNA repair, and molybdopterin biosynthesis. Our analysis reinforces recent findings suggesting that small noncoding RNAs are more common in Mycobacteria than previously expected. Our data provide a foundation for understanding the genome and biology of Mtb in a comparative context, and are available online and through TBDB.org.
has issue date	2012-03-28(xsd:dateTime)
bibo:doi	10.1186/1471-2164-13-120
bibo:pmid	22452820
has license	cc-by
sha1sum (hex)	28bec3efe92c8567992ee35baecf2dc42bbc34ae
schema:url	https://doi.org/10.1186/1471-2164-13-120
resource representing a document's title	Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis
has PubMed Central identifier	PMC3388012
has PubMed identifier	22452820
schema:publication	BMC Genomics
resource representing a document's body	covid:28bec3efe92c8567992ee35baecf2dc42bbc34ae#body_text
is schema:about of	named entity 'lipid metabolism' named entity 'expected' named entity 'promoter' named entity 'Corynebacteria' named entity 'Mycobacteria' named entity 'regulation' named entity 'COMPARATIVE ANALYSIS' named entity 'PATHOGENESIS' named entity 'PROTEIN EVOLUTION' named entity 'FINDINGS' named entity 'NEARLY' named entity 'UNDERSTAND' named entity 'GENE EXPRESSION DATA' named entity 'BUT' named entity 'REGULATORY' named entity 'ORG' named entity 'PREDICTED' named entity 'MYCOBACTERIA' named entity 'EXPRESSION' named entity 'BIFIDOBACTERIUM LONGUM' named entity 'UNDERSTANDING' named entity 'LIPID METABOLISM' named entity 'DATA' named entity 'NOCARDIA' named entity 'OBLIGATE' named entity 'STREPTOMYCES' named entity 'IDENTIFY' named entity 'UNSATURATED FATTY ACID METABOLISM' named entity 'CONSERVATION' named entity 'ANALYSIS' named entity 'ADAPTATION' named entity 'SATURATED' named entity 'RELATED' named entity '400' named entity 'CONFIRM' named entity 'GENE FAMILIES' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'COMPARATIVE GENOMICS' named entity 'ONLINE' named entity 'ACIDOTHERMUS CELLULOLYTICUS' named entity 'MTB' named entity 'INCLUDE' named entity 'VALIDATED' named entity 'CONSERVED' named entity 'SEQUENCES' named entity 'PROMOTER' named entity 'USING' named entity 'STRAINS' named entity 'RNAS' named entity 'ENVIRONMENTAL' named entity 'EVOLUTION' named entity 'SMALL' named entity 'MOLYBDOPTERIN COFACTORS' named entity 'REGULATION' named entity 'SEQUENCE' named entity 'GENES' named entity 'AVAILABLE' named entity 'PATHOGENIC' named entity 'BACTERIA PRESENT' named entity 'STRAIN' named entity 'FUNCTIONAL'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software