About: Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer
Creator	Carrara, Guia Parsons, Maddy Saraiva, Nuno Smith, Geoffrey
source	Medline; PMC
abstract	Golgi anti-apoptotic protein (GAAP), also known as transmembrane Bax inhibitor-1 motif-containing 4 (TMBIM4) or Lifeguard 4 (Lfg4), shares remarkable amino acid conservation with orthologues throughout eukaryotes, prokaryotes and some orthopoxviruses, suggesting a highly conserved function. GAAPs regulate Ca(2+) levels and fluxes from the Golgi and endoplasmic reticulum, confer resistance to a broad range of apoptotic stimuli, promote cell adhesion and migration via the activation of store-operated Ca(2+) entry, are essential for the viability of human cells, and affect orthopoxvirus virulence. GAAPs are oligomeric, multi-transmembrane proteins that are resident in Golgi membranes and form cation-selective ion channels that may explain the multiple functions of these proteins. Residues contributing to the ion-conducting pore have been defined and provide the first clues about the mechanistic link between these very different functions of GAAP. Although GAAPs are naturally oligomeric, they can also function as monomers, a feature that distinguishes them from other virus-encoded ion channels that must oligomerize for function. This review summarizes the known functions of GAAPs and discusses their potential importance in disease.
has issue date	2017-05-03(xsd:dateTime)
bibo:doi	10.1098/rsob.170045
bibo:pmid	28469007
has license	cc-by
sha1sum (hex)	28deef160eb2e879ffa3a4f025898a9690be0e7e
schema:url	https://doi.org/10.1098/rsob.170045
resource representing a document's title	Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer
has PubMed Central identifier	PMC5451544
has PubMed identifier	28469007
schema:publication	Open Biol
resource representing a document's body	covid:28deef160eb2e879ffa3a4f025898a9690be0e7e#body_text
is schema:about of	named entity 'GOLGI ANTI-APOPTOTIC PROTEIN' named entity 'CAMELS' named entity 'CALCIUM' named entity 'CHANNELS' named entity 'CANCER' named entity 'channels' named entity 'cancer' named entity 'Golgi anti-apoptotic protein' named entity 'membrane protein' named entity 'ion channel' named entity 'CMLV' named entity 'ovarian cancers' named entity 'virus' named entity 'extracellular space' named entity 'GAAP' named entity 'TNFa' named entity 'universal common ancestor' named entity 'peptide' named entity 'BI-1' named entity 'virus replication' named entity 'BI-1' named entity 'anti-apoptotic' named entity 'homeostasis' named entity 'apoptotic' named entity 'bacteria' named entity 'protein' named entity 'caspase-8' named entity 'M2 protein' named entity 'housekeeping gene' named entity 'GAAP' named entity 'microarray' named entity 'BI-1' named entity 'ATF4' named entity 'over-expressed' named entity 'BI-1' named entity 'Golgi' named entity 'cellular processes' named entity 'plasma membrane' named entity 'cell adhesion' named entity 'GAAP' named entity 'anti-apoptotic' named entity 'motif' named entity 'transmembrane segments' named entity 'viral infection' named entity 'muscle tissue' named entity 'inflammatory cells' named entity 'influenza virus' named entity 'osteosarcoma' named entity 'GAAP' named entity 'TNF-a' named entity 'hepatitis C virus' named entity 'GAAP' named entity 'Penicillium chrysogenum' named entity 'viruses' named entity 'housekeeping protein' named entity 'infection' named entity 'BI-1' named entity 'protein' named entity 'selectivity filter' named entity 'K v' named entity 'TMDs' named entity 'complementation' named entity 'tetramers' named entity 'apoptosis' named entity 'signalling pathways' named entity 'channel conductance' named entity 'phylogenetic analysis' named entity 'ion channel' named entity 'microarray database' named entity 'complement' named entity 'molecule' named entity 'coronavirus' named entity 'downregulating' named entity 'metastasis' named entity 'viruses' named entity 'metastatic' named entity 'upregulation' named entity 'HO-1'

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