About: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation

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About: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation
Creator	Baeza, Cristian Blamey, Rodrigo Cantwell, Tamara Diaz, Rodrigo Dreyse, Jorge Ferre, Andrés Jan, Sint Regueira, Tomás Van, Nicolette
Source	PMC
abstract	A previously healthy, 39-year-old obese farmer, arrived hypotensive and tachycardic, with fever, myalgia, headache, abdominal pain, diarrhea, and progressive dyspnea. Ten days before symptoms onset, he was in direct contact with mice and working in a contaminated drain. Patient laboratory showed acute kidney injury and thrombocytopenia. Chest X-ray exhibited bilateral diffuse interstitial infiltrates. First-line empirical antibiotics were started and influenza discarded. Patient evolved with severe respiratory failure, associated with hemoptysis, and rapidly severe hemodynamic compromise. Despite neuromuscular blockade and prone positioning, respiratory failure increased. Accordingly, veno-venous ECMO was initiated, with bilateral femoral extraction and jugular return. After ECMO connection, there was no significant improvement in oxygenation, and low pre-membrane saturations and low arterial PaO(2) of the membrane showed that we were out of the limits of the rated flow. Thus, a second membrane oxygenator was installed in parallel. Afterward, oxygenation improved, with subsequent perfusion enhancement. Regarding etiology, due to high suspicion index, Leptospira serology was performed, coming back positive and meropenem was maintained. The patient ultimately recovered and experience excellent outcome. The clinical relevance of the case is the scared evidence of leptospirosis-associated severe respiratory failure treated with ECMO. This experience emphasizes the importance of an optimal support, which requires enough membrane surface and flow for an obese, highly hyperdynamic patient, during this reversible disease. A high index of suspicion is needed for an adequate diagnosis of leptospirosis to implement the correct treatment, particularly in the association of respiratory failure, pulmonary hemorrhage, and an epidemiological-related context.
has issue date	2017-10-10(xsd:dateTime)
bibo:doi	10.1007/s10047-017-0998-x
bibo:pmid	29019017
has license	no-cc
sha1sum (hex)	28e3d7d64740e1b0c6b04865a5f8413bacad00ed
schema:url	https://doi.org/10.1007/s10047-017-0998-x
resource representing a document's title	Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation
has PubMed Central identifier	PMC7102126
has PubMed identifier	29019017
schema:publication	J Artif Organs
resource representing a document's body	covid:28e3d7d64740e1b0c6b04865a5f8413bacad00ed#body_text
is schema:about of	named entity 'emphasizes' named entity 'membrane oxygenation' named entity 'RESPIRATORY FAILURE' named entity 'suspicion' named entity 'needed' named entity 'severe' named entity 'membrane surface' named entity 'pulmonary hemorrhage' named entity 'extracorporeal membrane oxygenation' named entity 'Leptospirosis' named entity 'symptomatic treatment' named entity 'surgically repaired' named entity 'First-line' named entity 'hepatic' named entity 'incidence rate' named entity 'vancomycin' named entity 'diarrhea' named entity 'second-line' named entity 'etiology' named entity 'meropenem' named entity 'Uveitis' named entity 'Acyclovir' named entity 'mmHg' named entity 'cell membranes' named entity 'cephalosporins' named entity 'acute kidney injury' named entity 'genus' named entity 'oxygenator' named entity 'blood gas' named entity 'vicious cycle' named entity 'renal failure' named entity 'hepatic' named entity 'differential diagnosis' named entity 'vasculitis' named entity 'spirochetes' named entity 'First-line' named entity 'tracheobronchitis' named entity 'Preload' named entity 'tamponade' named entity 'index of suspicion' named entity 'vasoactive' named entity 'Hantavirus' named entity 'bronchoscopies' named entity 'hypotensive' named entity 'intubated' named entity 'left ventricle' named entity 'evolution' named entity 'cardiac index' named entity 'interstitial pneumonia' named entity 'ECMO' named entity 'ECMO' named entity 'respiratory tract' named entity 'echocardiography' named entity 'antibiotics' named entity 'vectors' named entity 'left ventricular ejection fraction' named entity 'epidemiological data' named entity 'multiorgan dysfunction' named entity 'cardiomyopathy' named entity 'antibiotics' named entity 'cannulated' named entity 'supportive therapy' named entity 'arterial blood gas' named entity 'fever' named entity 'ophthalmologic' named entity 'oxygen delivery' named entity 'ECMO' named entity 'flu-like symptoms' named entity 'multiorgan failure' named entity 'invasive mechanical ventilation' named entity 'risk factors' named entity 'ECMO' named entity 'acute respiratory distress syndrome'

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