About: Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks
Creator	Robertson, Gregory Lyons, Michael Frank, Chad Andrews, Jenna Asay, Bryce Ben-Hur, Asa Blue Edwards, Blake Lenaerts, Anne Muñoz Gutiérrez, Juan Podell, Brendan Ramey, Michelle Richard, Jameson
source	PMC
abstract	Efforts to develop effective and safe drugs for treatment of tuberculosis require preclinical evaluation in animal models. Alongside efficacy testing of novel therapies, effects on pulmonary pathology and disease progression are monitored by using histopathology images from these infected animals. To compare the severity of disease across treatment cohorts, pathologists have historically assigned a semi-quantitative histopathology score that may be subjective in terms of their training, experience, and personal bias. Manual histopathology therefore has limitations regarding reproducibility between studies and pathologists, potentially masking successful treatments. This report describes a pathologist-assistive software tool that reduces these user limitations, while providing a rapid, quantitative scoring system for digital histopathology image analysis. The software, called ‘Lesion Image Recognition and Analysis’ (LIRA), employs convolutional neural networks to classify seven different pathology features, including three different lesion types from pulmonary tissues of the C3HeB/FeJ tuberculosis mouse model. LIRA was developed to improve the efficiency of histopathology analysis for mouse tuberculosis infection models, this approach has also broader applications to other disease models and tissues. The full source code and documentation is available from https://Github.com/TB-imaging/LIRA.
has issue date	2020-04-08(xsd:dateTime)
bibo:doi	10.1038/s41598-020-62960-6
bibo:pmid	32269234
has license	cc-by
sha1sum (hex)	290233a9894cc9608e11fdf6172b186c55aa849f
schema:url	https://doi.org/10.1038/s41598-020-62960-6
resource representing a document's title	Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks
has PubMed Central identifier	PMC7142129
has PubMed identifier	32269234
schema:publication	Sci Rep
resource representing a document's body	covid:290233a9894cc9608e11fdf6172b186c55aa849f#body_text
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