About: Oral edible plant vaccine containing hypoallergen of American cockroach major allergen Per a 2 prevents roach-allergic asthma in a murine model

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Oral edible plant vaccine containing hypoallergen of American cockroach major allergen Per a 2 prevents roach-allergic asthma in a murine model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oral edible plant vaccine containing hypoallergen of American cockroach major allergen Per a 2 prevents roach-allergic asthma in a murine model
Creator	Chen, Yi-Hsing Chiang, Chu-Hui Lee, Mey-Fann Li, Ying-Lan Lin, Shyh-Jye Song, Pei-Pong Wang, Nancy
Source	PMC
abstract	BACKGROUND: American cockroaches (Periplaneta americana) are an important indoor allergen source and a major risk factor for exacerbations and poor control of asthma. We previously reported that allergen components from American cockroaches exhibit varying levels of pathogenicity. Sensitization to major American cockroach allergen, Per a 2, correlated with more severe clinical phenotypes among patients with allergic airway diseases. MATERIALS AND METHODS: In this study, we examined whether oral plant vaccine-encoding full-length Per a 2 clone-996 or its hypoallergenic clone-372 could exert a prophylactic role in Per a 2-sensitized mice. The cDNAs coding Per a 2–996 and Per a 2–372 were inserted into TuMV vector and expressed in Chinese cabbage. Adult female BALB/c mice were fed with the cabbage extracts for 21 days and subsequently underwent two-step sensitization with recombinant Per a 2. RESULTS: Per a 2-specific IgE measured by in-house ELISA in the sera of Per a 2-372-treated groups were significantly lower than in the control groups after allergen challenge but not the Per a 2-996-treated group. Moreover, Per a 2–372 vaccine markedly decreased airway hyper-responsiveness and infiltration of inflammatory cells into the lungs, as well as reduced mRNA expression of IL-4 and IL-13 in comparison with the control mice. CONCLUSION: Our data suggest that oral administration of edible plant vaccine encoding Per a 2 hypo-allergen may be used as a prophylactic strategy against the development of cockroach allergy.
has issue date	2018-07-30(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0201281
bibo:pmid	30059516
has license	cc-by
sha1sum (hex)	2906d781d6cac5a07bf2826f620a788e3f8432ef
schema:url	https://doi.org/10.1371/journal.pone.0201281
resource representing a document's title	Oral edible plant vaccine containing hypoallergen of American cockroach major allergen Per a 2 prevents roach-allergic asthma in a murine model
has PubMed Central identifier	PMC6066233
has PubMed identifier	30059516
schema:publication	PLoS One
resource representing a document's body	covid:2906d781d6cac5a07bf2826f620a788e3f8432ef#body_text
is schema:about of	named entity 'severe' named entity 'risk factor' named entity 'ORAL' named entity 'MURINE' named entity 'CONTAINING' named entity 'PREVENTS' named entity 'AIRWAY DISEASES' named entity 'LEVELS' named entity 'CLINICAL' named entity 'A MAJOR' named entity 'ALLERGEN' named entity 'COMPONENTS' named entity 'PHENOTYPES' named entity 'CONTROL' named entity 'EXHIBIT' named entity 'INDOOR ALLERGEN' named entity 'ALLERGEN' named entity 'SEVERE' named entity 'CORRELATED' named entity 'AMERICAN COCKROACH' named entity 'MAJOR' named entity 'POOR' named entity 'RISK FACTOR' named entity 'ASTHMA' named entity 'MAJOR' named entity 'EDIBLE PLANT' named entity 'PREVIOUSLY' named entity 'IMPORTANT' named entity 'REPORTED' named entity 'ALLERGIC ASTHMA' named entity 'MODEL' named entity 'ROACH' named entity 'AMERICAN COCKROACH' named entity 'VACCINE' named entity 'ALLERGIC' named entity 'PATIENTS' named entity 'COCKROACHES' named entity 'SOURCE' named entity 'SENSITIZATION' named entity 'AMERICAN' named entity 'VARYING' named entity 'PATHOGENICITY' covid:arg/2906d781d6cac5a07bf2826f620a788e3f8432ef named entity 'pathogenicity' named entity 'Sensitization' named entity 'allergen' named entity 'allergen' named entity 'American cockroach' named entity 'allergic' named entity 'edible plant' named entity 'vaccine' named entity 'murine' named entity 'methacholine' named entity 'cDNA' named entity 'saline' named entity 'Taichung' named entity 'viruses' named entity 'plant extract' named entity 'plant extract' named entity 'intraperitoneally' named entity 'supernatants' named entity 'Rochester, NY' named entity 'TNF-alpha' named entity 'airway hyperresponsiveness' named entity 'IL-6' named entity 'RNA' named entity 'interferon (IFN)-γ' named entity 'allergen' named entity 'formalin' named entity 'specific immunotherapy' named entity 'vector' named entity 'IL-10' named entity 'Japan' named entity 'allergic' named entity 'humid tropical'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software