About: Xenotransplantation panel for the detection of infectious agents in pigs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Xenotransplantation panel for the detection of infectious agents in pigs
Creator	Potter, Jennifer Prichard, Mark Conner, Shun Estrada, \| Gray, \| Hartline, Caroll James, Scott Ra', \| Tector, \|
Source	Medline; PMC
abstract	Recent advances in xenotransplantation have produced organs from pigs that are well tolerated in primate models because of genetic changes engineered to delete major antigens from donor animals. To ensure the safety of human transplant recipients, it will be essential to understand both the spectrum of infectious agents in donor pigs and their potential to be transmitted to immunocompromised transplant recipients. Equally important will be the development of new highly sensitive diagnostic methods for use in the detection of these agents in donor animals and for the monitoring of transplant recipients. Herein, we report results from a panel of 30 quantitative polymerase chain reaction (qPCR) assays for infectious agents with the potential to be transmitted to the human host. The reproducibility, sensitivity and specificity of each assay were evaluated and were found to exhibit analytic sensitivity that was similar to that of quantitative assays used to perform viral load testing of human viruses in clinical laboratories. This analytical approach was used to detect nucleic acids of infectious agents present in specimens from 9 sows and 22 piglets derived by caesarean section. The most commonly detected targets in adult animals were Mycoplasma species and two distinct herpesviruses, porcine lymphotrophic herpesvirus 2 and 3. A total of 14 piglets were derived from three sows infected with either or both herpesviruses, yet none tested positive for the viruses indicating that vertical transmission of these viruses is inefficient.
has issue date	2018-07-01(xsd:dateTime)
bibo:doi	10.1111/xen.12427
bibo:pmid	30264882
has license	bronze-oa
sha1sum (hex)	29089e5ebd7146e5d7f898eceb38648f7344ec9a
schema:url	https://doi.org/10.1111/xen.12427
resource representing a document's title	Xenotransplantation panel for the detection of infectious agents in pigs
has PubMed Central identifier	PMC6166664
has PubMed identifier	30264882
schema:publication	Xenotransplantation
resource representing a document's body	covid:29089e5ebd7146e5d7f898eceb38648f7344ec9a#body_text
is schema:about of	named entity 'donor' named entity 'xenotransplantation' named entity 'panel' named entity 'ensure' named entity 'primate' named entity 'antigens' named entity 'transplant recipients' named entity 'transplant recipients' named entity 'transplant recipients' named entity 'infectious agents' named entity 'high-quality' named entity 'cyclophilin' named entity 'porcine' named entity 'standard deviation' named entity 'clinical laboratory' named entity 'viruses' named entity 'viruses' named entity 'microbiological' named entity 'nucleotide sequence' named entity 'Piglets' named entity 'host range' named entity 'clinical laboratory' named entity 'HEV' named entity 'reovirus' named entity 'copy number' named entity 'human genes' named entity 'qPCR' named entity 'xenotransplantation' named entity 'major groups' named entity 'EMCV' named entity 'hepatitis E virus' named entity 'Circovirus' named entity 'organs for transplantation' named entity 'PEDV' named entity 'pig' named entity 'PHEV' named entity 'internal control' named entity 'Deidentified' named entity 'HEV' named entity 'caesarian section' named entity 'WNV' named entity 'copy number' named entity 'pathology' named entity 'nystatin' named entity 'viruses' named entity 'xenotransplantation' named entity 'virus' named entity 'qPCR' named entity 'transplanted tissue' named entity 'PERV' named entity 'porcine' named entity 'pig' named entity 'caesarian section' named entity 'coronavirus' named entity 'plasmids' named entity 'GraphPad Prism' named entity 'HEV' named entity 'viruses' named entity 'copy number' named entity 'HSV' named entity 'Molecular Diagnostic' named entity 'HHV6' named entity 'copy number' named entity 'copy number' named entity 'virus' named entity 'xenotransplantation' named entity 'copy number' named entity 'influenza B virus' named entity 'quantitative polymerase chain reaction' named entity 'base pair' named entity 'human subjects' named entity 'porcine' named entity 'Mycoplasma haemofelis'

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