About: Vimentin regulates activation of the NLRP3 inflammasome

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About: Vimentin regulates activation of the NLRP3 inflammasome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Vimentin regulates activation of the NLRP3 inflammasome
Creator	Davis, Jennifer Baker, Margaret Cheresh, Paul Kamp, David Kutuzov, Mikhail Lam, Anna Morales-Nebreda, Luisa Ridge, Karen Rogel, Micah Sennello, Joseph Shumaker, Dale Sitikov, Albert Troken, James Urich, Daniela Scott Budinger, G Dos Santos, Gimena
source	PMC
abstract	Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated the role of vimentin, a type III intermediate filament, in this process using three well-characterized murine models of ALI known to require NLRP3 inflammasome activation. We demonstrate that central pathophysiologic events in ALI (inflammation, IL-1β levels, endothelial and alveolar epithelial barrier permeability, remodelling and fibrosis) are attenuated in the lungs of Vim(−/−) mice challenged with LPS, bleomycin and asbestos. Bone marrow chimeric mice lacking vimentin have reduced IL-1β levels and attenuated lung injury and fibrosis following bleomycin exposure. Furthermore, decreased active caspase-1 and IL-1β levels are observed in vitro in Vim(−/−) and vimentin-knockdown macrophages. Importantly, we show direct protein–protein interaction between NLRP3 and vimentin. This study provides insights into lung inflammation and fibrosis and suggests that vimentin may be a key regulator of the NLRP3 inflammasome. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/ncomms7574) contains supplementary material, which is available to authorized users.
has issue date	2015-03-12(xsd:dateTime)
bibo:doi	10.1038/ncomms7574
bibo:pmid	25762200
has license	no-cc
sha1sum (hex)	296a164caf341b41f229d0c618959a6bfeb6a00c
schema:url	https://doi.org/10.1038/ncomms7574
resource representing a document's title	Vimentin regulates activation of the NLRP3 inflammasome
has PubMed Central identifier	PMC4358756
has PubMed identifier	25762200
schema:publication	Nat Commun
resource representing a document's body	covid:296a164caf341b41f229d0c618959a6bfeb6a00c#body_text
is schema:about of	named entity 'pathophysiologic' named entity 'chimeric' named entity 'NLRP3' named entity 'vimentin' named entity 'activation' named entity 'alveolar' named entity 'permeability' named entity 'Vim' named entity 'ALI' named entity 'protein-protein interaction' named entity 'epithelial barrier' named entity 'bleomycin' named entity 'Bone marrow' named entity 'pathophysiologic' named entity 'endothelial' named entity 'inflammasome' named entity 'inflammation' named entity 'NLRP3' named entity 'Vimentin' named entity 'IL-1b' named entity 'IL-1b' named entity 'NLRP3' named entity 'NLRP3' named entity 'ALI' named entity 'lung inflammation' named entity 'vimentin' named entity 'inflammation' named entity 'inflammasome' named entity 'inflammasome' named entity 'NLRP3' named entity 'caspase-1' named entity 'NLRP3' named entity 'asbestos' named entity 'ALI' named entity 'endothelial' named entity 'mice' named entity 'vimentin' named entity 'bleomycin' named entity 'lung injury' named entity 'BONE MARROW' named entity 'LUNG INJURY' named entity 'RESULTING IN' named entity 'PATHOPHYSIOLOGIC' named entity 'NLRP3' named entity 'LUNG INFLAMMATION' named entity 'ATTENUATED' named entity 'FOLLOWING' named entity 'MURINE' named entity 'LPS' named entity 'ALI' named entity 'EVENTS' named entity 'BLEOMYCIN EXPOSURE' named entity 'LACKING' named entity 'ACTIVE' named entity 'fibrosis' named entity 'IL-1b' named entity 'mice' named entity 'IL-1b' named entity 'vimentin' named entity 'macrophages' named entity 'LPS' named entity 'alveolar' covid:arg/296a164caf341b41f229d0c618959a6bfeb6a00c named entity 'STUDY' named entity 'DIRECT' named entity 'MAY BE A'

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