About: Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children

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About: Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children
Creator	Leruez-Ville, Marianne Moulin, Florence Levy, Michael Bendavid, Matthieu Chareyre, Judith Geslain, Guillaume Grimaud, Marion Jean, Sandrine Khraiche, Diala Léger, Pierre Marais, Clémence Oualha, Mehdi Poncelet, Géraldine Quartier, Pierre Renolleau, Sylvain Semaan, Nada Starck, Julie
Source	Medline; PMC
abstract	BACKGROUND: A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020. RESULTS: 20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25–55); troponin, 269 ng/mL (31–4607)), and arterial hypotension with mainly vasoplegic clinical presentation. The first symptoms before PICU admission were intense abdominal pain and fever for 6 days (1–10). All children had highly elevated C-reactive protein (> 94 mg/L) and procalcitonin (> 1.6 ng/mL) without microbial cause. At least one feature of Kawasaki disease was found in all children (fever, n = 20, skin rash, n = 10; conjunctivitis, n = 6; cheilitis, n = 5; adenitis, n = 2), but none had the typical form. SARS-CoV-2 PCR and serology were positive for 10 and 15 children, respectively. One child had both negative SARS-CoV-2 PCR and serology, but had a typical SARS-CoV-2 chest tomography scan. All children but one needed an inotropic/vasoactive drug support (epinephrine, n = 12; milrinone, n = 10; dobutamine, n = 6, norepinephrine, n = 4) and 8 were intubated. All children received intravenous immunoglobulin (2 g per kilogram) with adjuvant corticosteroids (n = 2), IL 1 receptor antagonist (n = 1) or a monoclonal antibody against IL-6 receptor (n = 1). All children survived and were afebrile with a full left ventricular function recovery at PICU discharge. CONCLUSIONS: Acute myocarditis with intense systemic inflammation and atypical Kawasaki disease is an emerging severe pediatric disease following SARS-CoV-2 infection. Early recognition of this disease is needed and referral to an expert center is recommended. A delayed and inappropriate host immunological response is suspected. While underlying mechanisms remain unclear, further investigations are required to target an optimal treatment.
has issue date	2020-06-01(xsd:dateTime)
bibo:doi	10.1186/s13613-020-00690-8
bibo:pmid	32488505
has license	cc-by
sha1sum (hex)	298834b4c203920b3b7b80b4244c1f255546470d
schema:url	https://doi.org/10.1186/s13613-020-00690-8
resource representing a document's title	Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children
has PubMed Central identifier	PMC7266128
has PubMed identifier	32488505
schema:publication	Ann Intensive Care
resource representing a document's body	covid:298834b4c203920b3b7b80b4244c1f255546470d#body_text
is schema:about of	named entity 'assessment' named entity 'emerging disease' named entity 'FEVER' named entity 'CHARACTERIZATION' named entity 'ASSESSMENT' named entity 'infection' named entity 'shock' named entity 'hypotensive' named entity 'Paris' named entity 'PICU' named entity 'SARS-CoV-2' named entity 'infection' named entity 'Paris' named entity 'fever' named entity 'infection' named entity 'fever' named entity 'Acute myocarditis' named entity 'critically ill' named entity 'inflammatory' named entity 'troponin' named entity 'R-Gene' named entity '1, 2' named entity 'renal replacement therapy' named entity 'Paris' named entity 'France' named entity 'infection' named entity 'immunological' named entity 'epidemic' named entity 'Kawasaki disease' named entity 'systolic dysfunction' named entity 'follow-up' named entity 'SARS-CoV-2' named entity 'oliguria' named entity 'respiratory failure' named entity 'tachycardia' named entity 'BioMérieux' named entity 'co-morbidity' named entity 'demographic data' named entity '1, 2' named entity 'systemic inflammation' named entity 'critically ill' named entity 'hypotensive' named entity 'study population' named entity 'coronavirus' named entity 'SARS-CoV-2' named entity 'informed consent' named entity 'nasopharyngeal swabs' named entity 'etiologies' named entity 'organ damage' named entity 'echocardiography' named entity 'SARS-CoV-2' named entity 'vasculitis' named entity 'Pericardial effusion' named entity 'PICU' named entity 'IgA' named entity 'acute renal failure' named entity 'receptor antagonist' named entity 'acute myocarditis' named entity 'serology' named entity 'Coronary arteries' named entity 'brain natriuretic peptide' named entity 'Kawasaki disease' named entity 'computed tomography scan' named entity 'Bussy-Saint-Martin' named entity 'depression'

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