About: Co‐localization of Middle East respiratory syndrome coronavirus (MERS‐CoV) and dipeptidyl peptidase‐4 in the respiratory tract and lymphoid tissues of pigs and llamas

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Co‐localization of Middle East respiratory syndrome coronavirus (MERS‐CoV) and dipeptidyl peptidase‐4 in the respiratory tract and lymphoid tissues of pigs and llamas Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Co‐localization of Middle East respiratory syndrome coronavirus (MERS‐CoV) and dipeptidyl peptidase‐4 in the respiratory tract and lymphoid tissues of pigs and llamas
Creator	Baumgärtner, Wolfgang Lehmbecker, Annika Segalés, Joaquim Te, Nigeer Vergara-Alert, Júlia Haagmans, Bart Bensaid, \| Mónica Pérez, \|
Source	Medline; PMC
abstract	This study investigated the co‐localization of the Middle East respiratory syndrome coronavirus (MERS‐CoV) and its receptor dipeptidyl peptidase‐4 (DPP4) by immunohistochemistry (IHC) across respiratory and lymphoid organs of experimentally MERS‐CoV infected pigs and llamas. Also, scanning electron microscopy was performed to assess the ciliary integrity of respiratory epithelial cells in both species. In pigs, on day 2 post‐inoculation (p.i.), DPP4‐MERS‐CoV co‐localization was detected in medial turbinate epithelium. On day 4 p.i., the virus/receptor co‐localized in frontal and medial turbinate epithelial cells in pigs, and epithelial cells distributed unevenly through the whole nasal cavity and in the cervical lymph node in llamas. MERS‐CoV viral nucleocapsid was mainly detected in upper respiratory tract sites on days 2 and 4 p.i. in pigs and day 4 p.i. in llamas. No MERS‐CoV was detected on day 24 p.i. in any tissue by IHC. While pigs showed severe ciliary loss in the nasal mucosa both on days 2 and 4 p.i. and moderate loss in the trachea on days 4 and 24 p.i., ciliation of respiratory organs in llamas was not significantly affected. Obtained data confirm the role of DPP4 for MERS‐CoV entry in respiratory epithelial cells of llamas. Notably, several nasal epithelial cells in pigs were found to express viral antigen but not DPP4, suggesting the possible existence of other molecule/s facilitating virus entry or down regulation of DPP4 upon infection.
has issue date	2018-12-28(xsd:dateTime)
bibo:doi	10.1111/tbed.13092
bibo:pmid	30520548
has license	cc-by-nc
sha1sum (hex)	298a64fc7158cb78592bd96d53b4e58fbf562276
schema:url	https://doi.org/10.1111/tbed.13092
resource representing a document's title	Co‐localization of Middle East respiratory syndrome coronavirus (MERS‐CoV) and dipeptidyl peptidase‐4 in the respiratory tract and lymphoid tissues of pigs and llamas
has PubMed Central identifier	PMC7027813
has PubMed identifier	30520548
schema:publication	Transbound Emerg Dis
resource representing a document's body	covid:298a64fc7158cb78592bd96d53b4e58fbf562276#body_text
is schema:about of	named entity 'EPITHELIAL CELLS' named entity 'DETECTED' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'LLAMAS' named entity 'INTEGRITY OF' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'DIPEPTIDYL PEPTIDASE' named entity 'MEDIAL' named entity 'INOCULATION' named entity 'SPECIES' named entity 'PERFORMED' named entity 'INFECTED' named entity 'FRONTAL' named entity 'POST' named entity 'ACROSS' named entity 'NASAL CAVITY' named entity 'species' named entity 'respiratory tract' named entity 'CO-LOCALIZATION' named entity 'CO-LOCALIZATION' named entity 'CILIARY' named entity 'SCANNING ELECTRON MICROSCOPY' named entity 'RESPIRATORY' named entity 'DISTRIBUTED' named entity 'EPITHELIUM' named entity 'PIGS' named entity 'RESPIRATORY TRACT' named entity 'LLAMAS' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'LYMPHOID TISSUES' named entity 'DIPEPTIDYL PEPTIDASE' named entity 'LOCALIZED' named entity 'ITS' named entity '28P' named entity 'DPP4' named entity 'DAY 4' named entity 'STUDY' named entity 'PIGS' named entity 'DAY 2' named entity 'CERVICAL LYMPH NODE' named entity 'RECEPTOR' named entity 'TURBINATE' named entity 'INVESTIGATED' named entity 'ASSESS' named entity 'VIRUS' named entity 'LYMPHOID ORGANS' covid:arg/298a64fc7158cb78592bd96d53b4e58fbf562276 named entity 'MERS-CoV' named entity 'DPP4' named entity 'respiratory' named entity 'DPP4' named entity 'receptor' named entity 'IHC' named entity 'epithelium' named entity 'virus' named entity 'receptor' named entity 'epithelial cells' named entity 'dipeptidyl peptidase-4' named entity 'Middle East respiratory syndrome coronavirus' named entity 'MERS-CoV' named entity 'virus' named entity 'DPP4' named entity 'Dromedary camels' named entity 'DPP4' named entity 'necropsy' named entity 'Scanning electron microscopy' named entity 'MERS-CoV' named entity 'upper respiratory tract' named entity 'tissue tropism' named entity 'euthanized' named entity 'scanning electron microscopy' named entity 'MERS-CoV' named entity 'Endogenous' named entity 'receptor'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software