About: Clinical aspects of 2009 pandemic influenza A (H1N1) virus infection in Austria

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About: Clinical aspects of 2009 pandemic influenza A (H1N1) virus infection in Austria Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical aspects of 2009 pandemic influenza A (H1N1) virus infection in Austria
Creator	Jones, N Schellongowski, Peter Hasibeder, Walter Jones, • Staudinger, Thomas Burgmann, Burgmann, • Chmelizek, Gregor Egle, • Flick, Holger Fritsche, • Gansinger, Lukas Gattringer, • Greil, Richard Grundbichler, Michael Halabi, Milo Hell, Hell, M Hell, • Herkner, Á Herkner, • Maass, M Maass, Viola Maass, • Poeppl, G Poeppl, M Poeppl, W Poeppl, Á Poeppl, • Pretsch, Ingrid Schurz-Bamieh, • Sperl, Wolfgang Stoiser, Á Stoiser, • Udo, Langenhorst Voith, Martina
Source	PMC
abstract	PURPOSE: To describe the clinical features, risk factors for severe disease and effectiveness of oseltamivir in patients with 2009 pandemic influenza A (H1N1) virus infection. METHODS: In a prospective, cross-sectional, multicentre study, data on 540 patients with confirmed 2009 H1N1 infection from seven Austrian hospitals were collected using a standardised online case-history form. RESULTS: The median age of the patients was 19.3 years (range 26 days–90.8 years); point-of-care testing yielded false-negative results in 60.2% of the 176 cases tested. The most common symptoms were fever, cough, fatigue and headache. Overall, 343 patients (63.5%) were hospitalised, 49 (9.1%) were admitted to an intensive care unit (ICU) and 14 (4.1%) died. Case fatality rates were highest (9.1%) in those aged 65 years or older. Factors significantly associated with a higher risk for ICU admission included age, neurological disease, adipositas, and both interstitial pathology and lobular pathology on chest X-ray. No association with pregnancy, malignancy or immunosuppressive therapy was detected. Antiviral treatment significantly reduced the duration of fever by 0.66 days and lowered the risk of ICU admission, but had no significant benefit on survival. CONCLUSIONS: During the 2009 H1N1 influenza pandemic, elderly or obese patients and those with neurological disease had an increased risk for severe H1N1 infection in Austria. Pregnancy was not associated with a higher risk for severe disease in the later phase of the 2009 H1N1 pandemic. Antiviral treatment provided a minimal effect on the symptoms of influenza but reduced the risk of admission to an ICU.
has issue date	2011-05-05(xsd:dateTime)
bibo:doi	10.1007/s15010-011-0121-9
bibo:pmid	21544585
has license	no-cc
sha1sum (hex)	2a27461bbce3d1cfe83d0302fbd4208102381c6f
schema:url	https://doi.org/10.1007/s15010-011-0121-9
resource representing a document's title	Clinical aspects of 2009 pandemic influenza A (H1N1) virus infection in Austria
has PubMed Central identifier	PMC7102306
has PubMed identifier	21544585
schema:publication	Infection
resource representing a document's body	covid:2a27461bbce3d1cfe83d0302fbd4208102381c6f#body_text
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