About: Current strategies and opportunities to manufacture cells for modeling human lungs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Current strategies and opportunities to manufacture cells for modeling human lungs
Creator	Karoubi, Golnaz Soleas, John Varma, Ratna Waddell, Thomas Mcguigan, Alison
Source	Elsevier; Medline; PMC
abstract	Chronic lung diseases remain major healthcare burdens, for which the only curative treatment is lung transplantation. In vitro human models are promising platforms for identifying and testing novel compounds to potentially decrease this burden. Directed differentiation of pluripotent stem cells is an important strategy to generate lung cells to create such models. Current lung directed differentiation protocols are limited as they do not 1) recapitulate the diversity of respiratory epithelium, 2) generate consistent or sufficient cell numbers for drug discovery platforms, and 3) establish the histologic tissue-level organization critical for modeling lung function. In this review, we describe how lung development has formed the basis for directed differentiation protocols, and discuss the utility of available protocols for lung epithelial cell generation and drug development. We further highlight tissue engineering strategies for manipulating biophysical signals during directed differentiation such that future protocols can recapitulate both chemical and physical cues present during lung development.
has issue date	2020-08-22(xsd:dateTime)
bibo:doi	10.1016/j.addr.2020.08.005
bibo:pmid	32835746
has license	no-cc
sha1sum (hex)	2a3d753e790abce94f2cc68bf329917f192d99bc
schema:url	https://doi.org/10.1016/j.addr.2020.08.005
resource representing a document's title	Current strategies and opportunities to manufacture cells for modeling human lungs
has PubMed Central identifier	PMC7442933
has PubMed identifier	32835746
schema:publication	Adv Drug Deliv Rev
resource representing a document's body	covid:2a3d753e790abce94f2cc68bf329917f192d99bc#body_text
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