About: Antiviral activity of cationic amphiphilic drugs

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Antiviral activity of cationic amphiphilic drugs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral activity of cationic amphiphilic drugs
Creator	Baritussio, Aldo Calistri, Arianna Palù, Giorgio Parolin, Cristina Salata, Cristiano
Source	Medline; PMC
abstract	Introduction: Emerging and reemerging viral infections represent a major concern for human and veterinary public health and there is an urgent need for the development of broad-spectrum antivirals. Areas covered: A recent strategy in antiviral research is based on the identification of molecules targeting host functions required for infection of multiple viruses. A number of FDA-approved drugs used to treat several human diseases are cationic amphiphilic drugs (CADs) that have the ability to accumulate inside cells affecting several structures/functions hijacked by viruses during infection. In this review we summarized the CADs’ chemical properties and effects on the cells and reported the main FDA-approved CADs that have been identified so far as potential antivirals in drug repurposing studies. Expert commentary: Although there have been concerns regarding the efficacy and the possible side effects of the off-label use of CADs as antivirals, they seem to represent a promising starting point for the development of broad-spectrum antiviral strategies. Further knowledge about their mechanism of action is required to improve their antiviral activity and to reduce the risk of side effects.
has issue date	2017-03-20(xsd:dateTime)
bibo:doi	10.1080/14787210.2017.1305888
bibo:pmid	28286997
has license	no-cc
sha1sum (hex)	2a5ec3f7d844b1e52bc25171a8ea4d6eaeae0015
schema:url	https://doi.org/10.1080/14787210.2017.1305888
resource representing a document's title	Antiviral activity of cationic amphiphilic drugs
has PubMed Central identifier	PMC7103695
has PubMed identifier	28286997
schema:publication	Expert Rev Anti Infect Ther
resource representing a document's body	covid:2a5ec3f7d844b1e52bc25171a8ea4d6eaeae0015#body_text
is schema:about of	named entity 'CADS' named entity 'COVERED' named entity 'MULTIPLE' named entity 'VETERINARY PUBLIC HEALTH' named entity 'MOLECULES' named entity 'REVIEW' named entity 'USED' named entity 'HUMAN DISEASES' named entity 'STRATEGY' named entity 'MECHANISM OF ACTION' named entity 'EFFECTS' named entity 'HUMAN' named entity 'BROAD' named entity 'DRUGS' named entity 'ANTIVIRAL ACTIVITY' named entity 'SPECTRUM' named entity 'EFFICACY' named entity 'REQUIRED' named entity 'TARGETING' named entity 'FDA' named entity 'TREAT' named entity 'AREAS' named entity 'AMPHIPHILIC' named entity 'ANTIVIRAL' named entity 'CHEMICAL PROPERTIES' named entity 'POTENTIAL' named entity 'APPROVED' named entity 'SIDE EFFECTS' named entity 'CELLS' named entity 'NEED FOR' named entity 'BASED' named entity 'FUNCTIONS' named entity 'NUMBER OF' named entity 'DEVELOPMENT' named entity 'TO REDUCE' named entity 'IDENTIFICATION' named entity 'VIRAL INFECTIONS' named entity 'STRUCTURES' named entity 'URGENT' named entity 'MAIN' named entity 'AFFECTING' named entity 'OFF-LABEL USE' named entity 'FAR' named entity 'KNOWLEDGE' named entity 'A MAJOR' named entity 'RECENT' named entity 'USE OF' named entity 'COMMENTARY' named entity 'REPORTED' named entity 'INFECTION' named entity 'VIRUSES' named entity 'ABOUT' named entity 'STUDIES' named entity 'REPRESENT' named entity 'POSSIBLE' named entity 'HOST' named entity 'AMPHIPHILIC' named entity 'CONCERN' named entity 'DRUGS' named entity 'INSIDE' named entity 'STRATEGIES' named entity 'ANTIVIRAL ACTIVITY' named entity 'HAVE' named entity 'RESEARCH' named entity 'IDENTIFIED' named entity 'DRUG' named entity 'THEIR' named entity 'ANTIVIRALS' named entity 'INTRODUCTION' named entity 'RISK OF' named entity 'STARTING POINT' covid:arg/2a5ec3f7d844b1e52bc25171a8ea4d6eaeae0015 named entity 'antiviral activity' named entity 'human diseases' named entity 'viruses' named entity 'amphiphilic' named entity 'viruses'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software