About: Tauroursodeoxycholic acid (TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2

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About: Tauroursodeoxycholic acid (TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tauroursodeoxycholic acid (TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2
Creator	Jiang, Chengyu Lu, Huijun Li, Xiao Jin, Ningyi Li, Ning Tian, Mingyao Zhang, Yanxu Wang, Hongliang Li, Zhiqing Wu, Shuangxiu Xu, Ruodan Zhu, Jindong
Source	Elsevier; Medline; PMC
abstract	Influenza is a persistent threat to human health and there is a continuing requirement for updating anti-influenza strategies. Initiated by observations of different endoplasmic reticulum (ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza (HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid (TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity, an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals.
has issue date	2019-02-15(xsd:dateTime)
bibo:doi	10.1016/j.scib.2018.08.013
bibo:pmid	32288967
has license	no-cc
sha1sum (hex)	2a8a83200b66ae807ce70d4e86ae189d4f3dbcce
schema:url	https://doi.org/10.1016/j.scib.2018.08.013
resource representing a document's title	Tauroursodeoxycholic acid (TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2
has PubMed Central identifier	PMC7104969
has PubMed identifier	32288967
schema:publication	Sci Bull (Beijing)
resource representing a document's body	covid:2a8a83200b66ae807ce70d4e86ae189d4f3dbcce#body_text
is schema:about of	named entity 'highly' named entity 'complement' named entity 'amantadine' named entity 'host' named entity 'host' named entity 'vivo' named entity 'proton' named entity 'channel' named entity 'PROTON CHANNEL' named entity 'PROTON' named entity 'EXPAND' named entity 'ROLE' named entity 'ANTIVIRAL' named entity 'RESPONSES' named entity 'PROTON CHANNEL ACTIVITY' named entity 'INFLUENZA' named entity 'EFFECT' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA' named entity 'OBSERVED' named entity 'UPDATING' named entity 'HOST CELLS' named entity 'STRATEGIES' named entity 'IN VIVO' named entity 'H1N1' covid:arg/2a8a83200b66ae807ce70d4e86ae189d4f3dbcce named entity 'IDENTIFICATION' named entity 'SEASONAL' named entity 'RATHER' named entity 'BIOLOGY' named entity 'VIRAL INFECTION' named entity 'INFLUENZA A' named entity 'TAUROURSODEOXYCHOLIC ACID' named entity 'VIRAL' named entity 'IDENTIFIED' named entity 'INTRACELLULAR UPTAKE' named entity 'PERSISTENT' named entity 'CURRENT' named entity 'THREAT' named entity 'IN VITRO' named entity 'OUR' named entity 'VIRAL' named entity 'INEFFICIENT' named entity 'CELLS' named entity 'UNDERSTANDING' named entity 'INFECTIONS' named entity 'TAUROURSODEOXYCHOLIC ACID' named entity 'PENETRATED' named entity 'REQUIREMENT' named entity 'DISRUPTING' named entity 'ABOLISHED' named entity 'HOST' named entity 'ITS' named entity 'DIFFERENT' named entity 'CONDUCTIVITY' named entity 'INHIBITOR' named entity 'APPLICATION' named entity 'MODULATING' named entity 'ALTERNATIVE' named entity 'HUMAN HEALTH' named entity 'H5N1' named entity 'VIRAL INFECTION' named entity 'OBSERVATIONS' named entity 'DISRUPTING' named entity 'IS A' named entity 'PROTON CHANNEL' named entity 'COMPLEMENT' named entity 'ER STRESS' named entity 'STATES' named entity 'AVAILABLE' named entity 'CONTINUING'

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