About: Host genetics determine susceptibility to avian influenza infection and transmission dynamics

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Host genetics determine susceptibility to avian influenza infection and transmission dynamics
Creator	Butter, Colin Sadeyen, Jean-Remy Mccauley, John Ascough, Stephanie Balkissoon, Devanand Boyd, Amy Mwangi, William Peroval, Marylene Ruiz-Hernandez, Raul Smith, Adrian Staines, Karen
Source	PMC
abstract	Host-genetic control of influenza virus infection has been the object of little attention. In this study we determined that two inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectively relatively resistant and susceptible to infection with the low pathogenicity influenza virus A/Turkey/England/647/77 as defined by substantial differences in viral shedding trajectories. Resistant birds, although infected, were unable to transmit virus to contact birds, as ultimately only the presence of a sustained cloacal shedding (and not oropharyngeal shedding) was critical for transmission. Restriction of within-bird transmission of virus occurred in the resistant line, with intra-nares or cloacal infection resulting in only local shedding and failing to transmit fully through the gastro-intestinal-pulmonary tract. Resistance to infection was independent of adaptive immune responses, including the expansion of specific IFNγ secreting cells or production of influenza-specific antibody. Genetic resistance to a novel H9N2 virus was less robust, though significant differences between host genotypes were still clearly evident. The existence of host-genetic determination of the outcome of influenza infection offers tools for the further dissection of this regulation and also for understanding the mechanisms of influenza transmission within and between birds.
has issue date	2016-06-09(xsd:dateTime)
bibo:doi	10.1038/srep26787
bibo:pmid	27279280
has license	cc-by
sha1sum (hex)	2aabf3a6ba52bfdd83a884673fd6e48c67b8727b
schema:url	https://doi.org/10.1038/srep26787
resource representing a document's title	Host genetics determine susceptibility to avian influenza infection and transmission dynamics
has PubMed Central identifier	PMC4899695
has PubMed identifier	27279280
schema:publication	Sci Rep
resource representing a document's body	covid:2aabf3a6ba52bfdd83a884673fd6e48c67b8727b#body_text
is schema:about of	named entity 'GENETICS' named entity 'DYNAMICS' named entity 'INFLUENZA INFECTION' named entity 'GENETIC RESISTANCE' named entity 'TRANSMISSION' named entity 'GENETIC' named entity 'MECHANISMS' named entity 'DISSECTION' named entity 'TRANSMISSION' named entity 'HOST' named entity 'DETERMINE' named entity 'SUSCEPTIBILITY' named entity 'AVIAN INFLUENZA' named entity 'INFLUENZA INFECTION' named entity 'TOOLS' named entity 'NOVEL' named entity 'UNDERSTANDING' named entity 'SIGNIFICANT' named entity 'GENOTYPES' named entity 'ROBUST' named entity 'DETERMINATION' named entity 'OUTCOME' named entity 'H9N2 VIRUS' named entity 'RESISTANCE TO' named entity 'BIRDS' named entity 'ANTIBODY' named entity 'INFLUENZA' named entity 'HOST' named entity 'REGULATION' covid:arg/2aabf3a6ba52bfdd83a884673fd6e48c67b8727b named entity 'robust' named entity 'mechanisms' named entity 'antibody' named entity 'genetic determination' named entity 'infection' named entity 'genetics' named entity 'virus' named entity 'streptomycin' named entity 'IgY' named entity 'host response' named entity 'haplotypes' named entity 'cloacal' named entity 'cloacal' named entity 'human population' named entity 'infection' named entity 'Turkey' named entity 'trypsin' named entity 'avian influenza' named entity 'serological' named entity 'IFN' named entity 'Line 0' named entity 'antibody' named entity 'Genetic resistance' named entity 'H7N7' named entity 'cloacal' named entity 'haplotype' named entity 'viral replication' named entity 'Mice' named entity 'goat' named entity 'chicken' named entity '20.6' named entity 'gene' named entity 'plaque assay' named entity 'infection' named entity 'poultry' named entity 'IFN' named entity 'cloacal' named entity 'conventional selective breeding' named entity 'viral titers' named entity 'genetic control' named entity 'infection'

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