About: Clinical Impact of Community‐Acquired Respiratory Viruses on Bronchiolitis Obliterans After Lung Transplant

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About: Clinical Impact of Community‐Acquired Respiratory Viruses on Bronchiolitis Obliterans After Lung Transplant Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical Impact of Community‐Acquired Respiratory Viruses on Bronchiolitis Obliterans After Lung Transplant
Creator	Humar, Atul Kumar, Deepali Tellier, Raymond Erdman, Dean Peret, Teresa Keshavjee, Shaf Hadjiliadis, Denis Ayers, Melissa Johnson, Grant Siegal, Deborah
Source	PMC
abstract	Community‐acquired viral respiratory tract infections (RTI) in lung transplant recipients may have a high rate of progression to pneumonia and can be a trigger for immunologically mediated detrimental effects on lung function. A cohort of 100 patients was enrolled from 2001 to 2003 in which 50 patients had clinically diagnosed viral RTI and 50 were asymptomatic. All patients had nasopharyngeal and throat swabs taken for respiratory virus antigen detection, culture and RT‐PCR. All patients had pulmonary function tests at regular intervals for 12 months. Rates of rejection, decline in forced expiratory volume (L) in 1 s (FEV‐1) and bacterial and fungal superinfection were compared at the 3‐month primary endpoint. In the 50 patients with RTI, a microbial etiology was identified in 33 of 50 (66%) and included rhinovirus (9), coronavirus (8), RSV (6), influenza A (5), parainfluenza (4) and human metapneumovirus (1). During the 3‐month primary endpoint, 8 of 50 (16%) RTI patients had acute rejection versus 0 of 50 non‐RTI patients (p = 0.006). The number of patients experiencing a 20% or more decline in FEV‐1 by 3 months was 9 of 50 (18%) RTI versus 0 of 50 non‐RTI (0%) (p = 0.003). In six of these nine patients, the decline in FEV‐1 was sustained over a 1‐year period consistent with bronchiolitis obliterans syndrome (BOS). Community‐acquired respiratory viruses may be associated with the development of acute rejection and BOS.
has issue date	2005-06-02(xsd:dateTime)
bibo:doi	10.1111/j.1600-6143.2005.00971.x
has license	no-cc
sha1sum (hex)	2aada329a0cde26b24265c3cdc4d55d2ca72abd1
schema:url	https://doi.org/10.1111/j.1600-6143.2005.00971.x
resource representing a document's title	Clinical Impact of Community‐Acquired Respiratory Viruses on Bronchiolitis Obliterans After Lung Transplant
has PubMed Central identifier	PMC7187759
schema:publication	Am J Transplant
resource representing a document's body	covid:2aada329a0cde26b24265c3cdc4d55d2ca72abd1#body_text
is schema:about of	named entity 'primary endpoint' named entity 'microbial' named entity 'FORCED EXPIRATORY VOLUME' named entity 'RATES' named entity '288' named entity 'EFFECTS' named entity 'VIRAL' named entity 'SUSTAINED' named entity 'NON-' named entity '12 MONTHS' named entity 'INCLUDED' named entity 'RT-PCR' named entity 'RESPIRATORY VIRUSES' named entity 'acute rejection' named entity 'effects' named entity 'compared' named entity 'pulmonary function tests' named entity 'immunologically' named entity 'RTI' named entity 'development' named entity 'microbial' named entity 'influenza' named entity 'forced expiratory volume' named entity 'parainfluenza' named entity 'bronchiolitis obliterans' named entity 'FEV' named entity 'acute rejection' named entity 'primary endpoint' named entity 'CMV' named entity 'clinical diagnosis' named entity 'Sputum' named entity 'viral pneumonia' named entity 'nucleic acid' named entity 'research ethics board' named entity 'RT-PCR' named entity 'community-acquired' named entity 'antivirals' named entity 'SARS coronavirus' named entity 'Informed consent' named entity 'RTI' named entity 'obliterative bronchiolitis' named entity 'RTI' named entity 'sequelae' named entity 'assay' named entity 'RTI' named entity 'viral infection' named entity 'RTI' named entity 'lung transplant' named entity 'RSV' named entity 'picornavirus' named entity 'cough reflex' named entity 'HCoV-NL63' named entity 'biopsy' named entity 'pulmonary disease' named entity 'RTI' named entity 'RSV' named entity 'RTI' named entity 'lung transplant' named entity 'RTI' named entity 'lung transplant' named entity 'biopsy' named entity 'coronavirus' named entity 'RTI' named entity 'coronaviruses' named entity 'lumen' named entity 'Oligonucleotide primers' named entity 'actin' named entity 'community-acquired' named entity 'cyclosporin' named entity 'viremia' named entity 'immunosuppression' named entity 'asymptomatic patients' named entity 'bronchitis' named entity 'RTI'

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