About: Calming the Cytokine Storm - Splenic Ultrasound for Treating Inflammatory Disorders and Potentially COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Calming the Cytokine Storm - Splenic Ultrasound for Treating Inflammatory Disorders and Potentially COVID-19
Creator	Graham, Rachel Tracey, Kevin Affiliations, ¶ Agostino, Catherine Ashe, Jeffrey Binstadt, Bryce Chavan, Sangeeta Coleman, Thomas Cotero, Victoria Graf, John Kaiser, Claire Lim, Hubert Ntiloudi, Despoina Pellerito, John Peterson, Erik Puleo, Christopher Wallace, Kirk Zachs, Daniel Zanos, Stavros
source	MedRxiv
abstract	Hyperinflammation and uncontrolled cytokine release, which can be seen in severe cases of COVID-19, require therapy to reduce the innate immune response without hindering necessary adaptive immune mechanisms. Here, we show results from the first in-human trials using non-invasive ultrasound stimulation of the spleen to reduce cytokine release in the context of both an acute response in healthy subjects and a chronic inflammatory condition in rheumatoid arthritis patients. Splenic ultrasound results in a reduction in TNF serum levels, as well as IL-1B; and IL-8 transcript levels in monocytes. There is also a down regulation of pathways involved in TNF and IL-6 production, and IFNgamma- and NFKB-regulated genes. Many of these cytokines or pathways are upregulated in COVID-19 patients. There is also a reduction in chemokine transcript levels and other components of the chemotactic response, suggesting that reduction of cellular migration may contribute to the therapeutic effects of ultrasound. There is no inhibition of the adaptive immune response with ultrasound treatment relating to antibody production. This is consistent with a pre-clinical animal model where enhanced antibody production was achieved with splenic ultrasound. Therefore, this new splenic ultrasound approach has the potential to treat acute and chronic hyper-inflammatory diseases, as it lowers cytokine levels without disrupting the normal adaptive immune response. Portable ultrasound technologies are currently being developed and translated to the clinic to treat various inflammatory disorders, with more recent efforts directed towards combatting the hyperinflammation or cytokine storm in COVID-19 patients.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1101/2020.07.14.20153528
has license	medrxiv
sha1sum (hex)	2ac228ffe1cb1f1f0466a784ced88310b0b3abb3
schema:url	https://doi.org/10.1101/2020.07.14.20153528
resource representing a document's title	Calming the Cytokine Storm - Splenic Ultrasound for Treating Inflammatory Disorders and Potentially COVID-19
resource representing a document's body	covid:2ac228ffe1cb1f1f0466a784ced88310b0b3abb3#body_text
is schema:about of	named entity 'cytokines' named entity 'antibody' named entity 'stimulation' named entity 'Cytokine' named entity 'Ultrasound' named entity 'treat' named entity 'production' named entity 'technologies' named entity 'upregulated' named entity 'inflammatory' named entity 'involved' named entity 'therapy' named entity 'severe' named entity 'chemotactic' named entity 'adaptive immune response' named entity 'immune mechanisms' named entity 'chronic' named entity 'acute response' named entity 'acute' named entity 'ultrasound' named entity 'reduction' named entity 'cases' named entity 'IL-8' named entity 'TNF' named entity 'developed' named entity 'Disorders' named entity 'innate immune response' named entity 'IL-8' named entity 'Hyperinflammation' named entity 'COVID' named entity 'inflammatory disorders' named entity 'rheumatoid arthritis' named entity 'COVID' named entity 'hyperinflammation' named entity 'therapeutic effects' named entity 'pre-clinical' named entity 'ultrasound' named entity 'IFNγ' named entity 'Cytokine Storm' named entity 'Inflammatory Disorders' named entity 'inflammatory arthritis' named entity 'spleen' named entity 'ultrasound' named entity 'bronchoalveolar lavage fluid' named entity 'anti-inflammatory' named entity 'ultrasound' named entity 'antigen' named entity 'CD8+ T cells' named entity 'proinflammatory' named entity 'region of the abdomen' named entity 'COVID' named entity 'vagus nerve' named entity 'antigen' named entity 'ultrasound' named entity 'JAK/STAT pathway' named entity 'ultrasound' named entity 'IL-6' named entity 'IL-10' named entity 'chronic inflammation' named entity 'innate immunity' named entity 'Gene Ontology' named entity 'DARPA' named entity 'anti-inflammatory' named entity 'p-values' named entity 'down-regulation' named entity 'cytokine' named entity 'isoflurane'

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