About: A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization
Creator	Niccolai, Neri Spiga, Ottavia Trezza, Alfonso Bianchini, Monica Bongini, Pietro
Source	Elsevier; Medline; PMC
abstract	Abstract The recent release of COVID-19 spike glycoprotein allows detailed analysis of the structural features that are required for stabilizing the infective form of its quaternary assembly. Trying to disassemble the trimeric structure of COVID-19 spike glycoprotein, we analyzed single protomer surfaces searching for concave moieties that are located at the three protomer-protomer interfaces. The presence of some druggable pockets at these interfaces suggested that some of the available drugs in Drug Bank could destabilize the quaternary spike glycoprotein formation by binding to these pockets, therefore interfering with COVID-19 life cycle. The approach we propose here can be an additional strategy to fight against the deadly virus. Ligands of COVID-19 spike glycoprotein that we have predicted in the present computational investigation, might be the basis for new experimental studies in vitro and in vivo.
has issue date	2020-04-09(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2020.04.007
bibo:pmid	32451080
has license	els-covid
sha1sum (hex)	2ad9b7992f37afd377076317f9e5f56d19937c8b
schema:url	https://doi.org/10.1016/j.bbrc.2020.04.007
resource representing a document's title	A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization
has PubMed Central identifier	PMC7144664
has PubMed identifier	32451080
schema:publication	Biochem Biophys Res Commun
resource representing a document's body	covid:2ad9b7992f37afd377076317f9e5f56d19937c8b#body_text
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