About: Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection
Creator	Li, Wei Chen, Xiaoping Wu, Wenjuan Fang, Minghao Author's Affiliation, Liu, Furong Long, Xin Zhang, Bixiang Zhang, Wanguang Zhang, Zhanguo Zou, Wenbin
source	MedRxiv
abstract	The ongoing outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in the end of 2019 in China has triggered a global public health crisis. Previous studies have shown that SARS-CoV-2 infects cells by binding angiotensin-converting enzyme 2 (ACE2), which is the same as SARS-CoV. The expression and distribution of ACE2 in the pancreas are unknown. At the same time, the injury of pancreas after SARS-CoV-2 infection has not been concerned. Here, we collected public datasets (bulk RNA-seq and single-cell RNA-seq) to indicate the expression and the distribution of ACE2 in pancreas (in both exocrine glands and islets). And further, clinical data including mild and severe patients with COVID-19 demonstrated there existed mild pancreatitis. In the 67 severe cases, 11 patients (16.41%) showed elevated levels of both amylase and lipase, and 5 patients (7.46%) showed imaging alterations. Only one patient (1.85%) showed elevated levels of both amylase and lipase in 54 mild cases, without imaging changes. Our study revealed the phenomenon and possible cause of mild pancreatic injury in patients with COVID-19. This suggests that pancreatitis after SARS-CoV-2 infection should also be paid attention in clinical work.
has issue date	2020-03-03(xsd:dateTime)
bibo:doi	10.1101/2020.02.28.20029181
has license	medrxiv
sha1sum (hex)	2af91bbb625d983d5ad3aadb9e5f1d82268a0f1f
schema:url	https://doi.org/10.1101/2020.02.28.20029181
resource representing a document's title	Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection
resource representing a document's body	covid:2af91bbb625d983d5ad3aadb9e5f1d82268a0f1f#body_text
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