About: Prospects for the treatment of drug-resistant malaria parasites

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Prospects for the treatment of drug-resistant malaria parasites
Creator	Bray, Patrick Me, Timothy Tilley, Leann
source	PMC
abstract	Widespread parasitic resistance has led to an urgent need for the development and implementation of new drugs for the treatment of Plasmodium falciparum malaria. Artemisinin and its derivatives are becoming increasingly important, used preferably in combination with a second antimalarial agent to increase the efficacy and slow the development of resistance. However, cost, production and pharmacological issues associated with artemisinin derivatives and potential partner drugs are hindering the implementation of combination therapies. This article reviews the molecular basis of the action of, and resistance to, different antimalarials and examines the prospects for the next generation of drugs to combat this potentially lethal human pathogen.
has issue date	2006-06-26(xsd:dateTime)
bibo:doi	10.2217/17460913.1.1.127
bibo:pmid	17661691
has license	cc-by
sha1sum (hex)	2b0dcaa9688cdcb041366d5769e4e2b9b9deab0a
schema:url	https://doi.org/10.2217/17460913.1.1.127
resource representing a document's title	Prospects for the treatment of drug-resistant malaria parasites
has PubMed Central identifier	PMC7117597
has PubMed identifier	17661691
schema:publication	Future Microbiol
resource representing a document's body	covid:2b0dcaa9688cdcb041366d5769e4e2b9b9deab0a#body_text
is schema:about of	named entity 'Prospects' named entity 'parasites' named entity 'malaria parasites' named entity 'ferrous iron' named entity 'Africa' named entity 'Coartem' named entity 'malaria' named entity 'Africa' named entity 'malaria' named entity 'antimalarials' named entity 'aminoquinoline' named entity 'chlorpheniramine' named entity 'antimalarials' named entity 'parasites' named entity 'malaria parasites' named entity 'quinine' named entity 'hemozoin' named entity 'P. falciparum' named entity 'preventative treatment' named entity 'artemisinin' named entity 'drug resistance' named entity 'artemisinin' named entity 'neurotoxicity' named entity 'ACT' named entity 'digestive vacuole' named entity 'mechanism of action' named entity 'Brain stem' named entity 'pyrimethamine' named entity 'cytosol' named entity 'antimalarial' named entity 'quinoline' named entity 'organelles' named entity 'quinine' named entity 'GSK' named entity 'heme detoxification' named entity 'hematin' named entity 'drug resistance' named entity 'drug resistance' named entity 'polymorphism' named entity 'enzyme' named entity 'P. falciparum' named entity 'malaria' named entity 'parasite' named entity 'pregnant women' named entity 'digestive vacuole' named entity '4-aminophenol' named entity 'P. falciparum' named entity 'China' named entity 'artemether' named entity 'Novartis' named entity 'lipophilic' named entity 'South-East Asia' named entity 'half-life' named entity 'quinoline' named entity 'severe malaria' named entity 'drug-resistant' named entity 'ozone' named entity 'sub-Saharan' named entity 'parasites' named entity 'Sanofi-Aventis' named entity 'Africa' named entity 'parasites' named entity 'South Pacific region' named entity 'fetal' named entity 'quinine' named entity 'hydrophobic' named entity 'parasites' named entity 'amino acid' named entity 'malaria' named entity 'mefloquine' named entity 'artemisinin combination therapy' named entity 'P. falciparum' named entity 'piperaquine' named entity 'heme' named entity '4-aminoquinoline' named entity 'antimalarials' named entity 'hemolysis' named entity 'parasite' named entity 'antimalarial drugs'

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