About: Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case

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About: Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case
Creator	Song, Qifa Fan, Lingyan Gao, Guosheng Huang, Zuoan Shi, Qiaoyun Sun, Yedan Ye, Shuyuan Zhu, Zhe
source	Medline; PMC
abstract	BACKGROUND: The viral persistence in patients with Coronavirus Disease 2019 (COVID-19) remains to be investigated. METHODS: We investigated the viral loads, therapies, clinical features, and immune responses in a 70-year patient tested positive for SARS-CoV-2 for 3 months. FINDINGS: The patient exhibited the highest prevalence of abnormal indices of clinical features and immune responses at the first admission, including fever (38.3 ℃), decreased lymphocytes (0.83 × 10(9)/L) and serum potassium (3.1 mmol/L), as well as elevated serum creatinine (115 µmol/L), urea (8.6 mmol/L), and C-reactive protein (80 mg/L). By contrast, at the second and the third admission, these indices were all normal. Through three admissions, IL-2 increased from 0.14 pg/mL, 0.69 pg/mL, to 0.91 pg/mL, while IL-6 decreased from 11.78 pg/mL, 1.52 pg/mL, to 0.69 pg/mL, so did IL-10 from 5.13 pg/mL, 1.85 pg/mL, to 1.75 pg/mL. The steady declining trend was also found in TNF-α (1.49, 1.15, and 0.85 pg/mL) and IFN-γ (0.64, 0.42, and 0.27 pg/mL). The threshold cycle values of RT-PCR were 26.1, 30.5, and 23.5 for ORFlab gene, and 26.2, 30.6, and 22.7 for N gene, showing the patient had higher viral loads at the first and the third admission than during the middle term of the disease. The patient also showed substantially improved acute exudative lesions on the chest CT scanning images. CONCLUSIONS: The patient displayed declining immune responses in spite of the viral shedding for 3 months. We inferred the declining immune responses might result from the segregation of the virus from the immune system.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.1007/s15010-020-01485-6
bibo:pmid	32725596
has license	no-cc
sha1sum (hex)	2b1ceb2458380462818391a10779d4fe7813c3d3
schema:url	https://doi.org/10.1007/s15010-020-01485-6
resource representing a document's title	Absent immune response to SARS-CoV-2 in a 3-month recurrence of coronavirus disease 2019 (COVID-19) case
has PubMed Central identifier	PMC7386381
has PubMed identifier	32725596
schema:publication	Infection
resource representing a document's body	covid:2b1ceb2458380462818391a10779d4fe7813c3d3#body_text
is schema:about of	named entity 'immune responses' named entity 'immune system' named entity 'normal' named entity 'serum' named entity 'RT-PCR' named entity 'indices' named entity 'values' named entity 'immune responses' named entity 'mmol/L' named entity 'SARS-CoV-2' named entity 'DID' named entity 'INVESTIGATED' named entity 'CLINICAL FEATURES' named entity 'MMOL' named entity 'ACUTE' named entity 'SEGREGATION' covid:arg/2b1ceb2458380462818391a10779d4fe7813c3d3 named entity 'abnormal' named entity 'patient' named entity 'immune responses' named entity 'µmol' named entity 'IL-2' named entity 'patients' named entity 'CT scanning' named entity 'patient' named entity 'patient' named entity 'lymphocytes' named entity 'positive' named entity 'lesions' named entity 'potassium' named entity 'result' named entity 'lymphocytes' named entity 'TNF-α' named entity 'pg/mL' named entity 'immune responses' named entity 'viral shedding' named entity 'RT-PCR' named entity 'serum' named entity 'mmol/L' named entity 'clinical features' named entity 'pg/mL' named entity 'pg/mL' named entity 'pg/mL' named entity 'potassium' named entity 'IFN-γ' named entity 'coronavirus disease 2019' named entity 'SARS-CoV-2' named entity 'influenza' named entity 'inhalation' named entity 'Written consent' named entity 'COVID' named entity 'SARS-CoV-2' named entity 'invasive mechanical ventilation' named entity 'COVID' named entity 'IFN-γ' named entity 'lymphocyte' named entity 'IL-2' named entity 'CRP' named entity 'reverse transcription' named entity 'CT scanning' named entity 'IL-6' named entity 'SARS-CoV-2' named entity 'alveoli' named entity 'symptom' named entity 'urea' named entity 'SARS-CoV-2' named entity 'PCR' named entity 'cytokines' named entity 'compromised immunity' named entity 'nasopharyngeal swab' named entity 'nucleocapsid' named entity 'lymphocytes' named entity 'follow-up' named entity 'antiviral agents'

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