About: δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities
Creator	Tian, Ye Zhang, Zhentao Ye, Keqiang
Source	PMC
abstract	Mammalian asparagine endopeptidase (AEP) is a cysteine protease that cleaves its protein substrates on the C-terminal side of asparagine residues. Converging lines of evidence indicate that AEP may be involved in the pathogenesis of several neurological diseases, including Alzheimer’s disease, Parkinson’s disease, and frontotemporal dementia. AEP is activated in the aging brain, cleaves amyloid precursor protein (APP) and promotes the production of amyloid-β (Aβ). We renamed AEP to δ-secretase to emphasize its role in APP fragmentation and Aβ production. AEP also cleaves other substrates, such as tau, α-synuclein, SET, and TAR DNA-binding protein 43, generating neurotoxic fragments and disturbing their physiological functions. The activity of δ-secretase is tightly regulated at both the transcriptional and posttranslational levels. Here, we review the recent advances in the role of δ-secretase in neurodegenerative diseases, with a focus on its biochemical properties and the transcriptional and posttranslational regulation of its activity, and discuss the clinical implications of δ-secretase as a diagnostic biomarker and therapeutic target for neurodegenerative diseases.
has issue date	2020-01-06(xsd:dateTime)
bibo:doi	10.1186/s40035-019-0179-3
bibo:pmid	31911834
has license	cc-by
sha1sum (hex)	2b1eca915f6b652097c7070c69c0dc15daaaca7e
schema:url	https://doi.org/10.1186/s40035-019-0179-3
resource representing a document's title	δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities
has PubMed Central identifier	PMC6943888
has PubMed identifier	31911834
schema:publication	Transl Neurodegener
resource representing a document's body	covid:2b1eca915f6b652097c7070c69c0dc15daaaca7e#body_text
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