About: DNA vaccination protects mice against Zika virus-induced damage to the testes

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About: DNA vaccination protects mice against Zika virus-induced damage to the testes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	DNA vaccination protects mice against Zika virus-induced damage to the testes
Creator	Boivin, Guy Safronetz, David Racine, Trina Audet, Jonathan Muthumani, Kar Kobasa, Darwyn Bello, Alexander Kobinger, Gary Maslow, Joel Soule, Geoff Embury-Hyatt, Carissa De Graff, Christine Hagan, Mable Kucas, Stephanie Lindsay, Robbin Majer, Anna Piret, Jocelyne Ranadheera, Charlene Scharikow, Leanne Scott, Jennifer Smid, Valerie Booth, Stephanie Griffin, Bryan Kim, J Park, Young Sardesai, Niranjan Weiner, David De, Marc-Antoine Frost, Kathy Mctavish, Gordon Stein, Derek Tran, Kaylie Vega, La Warner, Bryce Yao, Xiao-Jian
Source	PMC
abstract	Zika virus (ZIKV) is an emerging pathogen causally associated with serious sequelae in fetuses, inducing fetal microcephaly and other neurodevelopment defects. ZIKV is primarily transmitted by mosquitoes, but can persist in human semen and sperm, and sexual transmission has been documented. Moreover, exposure of type-I interferon knockout mice to ZIKV results in severe damage to the testes, epididymis and sperm. Candidate ZIKV vaccines have shown protective efficacy in preclinical studies carried out in animal models, and several vaccines have entered clinical trials. Here, we report that administration of a synthetic DNA vaccine encoding ZIKV pre-membrane and envelope (prME) completely protects mice against ZIKV-associated damage to the testes and sperm and prevents viral persistence in the testes following challenge with a contemporary strain of ZIKV. These data suggest that DNA vaccination merits further investigation as a potential means to reduce ZIKV persistence in the male reproductive tract.
has issue date	2017-06-07(xsd:dateTime)
bibo:doi	10.1038/ncomms15743
bibo:pmid	28589934
has license	cc-by
sha1sum (hex)	2b38999c47f55f18f27ce6dc678dc2b4df381043
schema:url	https://doi.org/10.1038/ncomms15743
resource representing a document's title	DNA vaccination protects mice against Zika virus-induced damage to the testes
has PubMed Central identifier	PMC5467228
has PubMed identifier	28589934
schema:publication	Nat Commun
resource representing a document's body	covid:2b38999c47f55f18f27ce6dc678dc2b4df381043#body_text
is schema:about of	named entity 'PRECLINICAL STUDIES' named entity 'RESULTS' named entity 'SUGGEST' named entity 'STRAIN' named entity 'PREVENTS' named entity 'ENCODING' named entity 'HAVE' named entity 'DAMAGE' named entity 'MICE' named entity 'SYNTHETIC DNA' named entity 'VIRAL PERSISTENCE' named entity 'TYPE' named entity 'causally' named entity 'POTENTIAL' named entity 'TRANSMITTED BY' named entity 'EMERGING PATHOGEN' named entity 'THESE' named entity 'TESTES' named entity 'MEANS' named entity 'COMPLETELY' named entity 'SPERM' named entity 'FOLLOWING' named entity 'MALE REPRODUCTIVE TRACT' named entity 'SEMEN' named entity 'HUMAN' named entity 'NEURODEVELOPMENT' named entity 'HERE' named entity 'SEQUELAE' named entity 'PRE' named entity 'SEVERE' named entity 'ARTICLE' named entity 'INDUCED' named entity 'TESTES' named entity 'DNA VACCINATION' named entity 'MICE' named entity 'ZIKA VIRUS' named entity 'ASSOCIATED WITH' named entity 'CHALLENGE' named entity 'ADMINISTRATION' named entity 'DNA VACCINATION' named entity 'MEMBRANE' named entity 'EPIDIDYMIS' named entity 'DOCUMENTED' named entity 'FETAL MICROCEPHALY' named entity 'BUT' named entity 'ENTERED' named entity 'EXPOSURE'

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