About: Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
Creator	Deng, Hongkui Li, Cheng Chen, Wenhan Sun, Qi Cai, Yusheng Chen, Han Ji, Yin Luo, Tuoping Wang, Longteng Wang, Yuting Xue, Anqi Yu, Xiaojie Zhou, Huanhuan Zhu, Yinhua
Source	Medline; PMC
abstract	Cellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms, contributes to tissue dysfunction, and drives age-related phenotypes. The clearance of senescent cells is expected to decrease chronic, low-grade inflammation and improve tissue repair capacity, thus attenuating the decline of physical function in aged organisms. However, selective and effective clearance of senescent cells of different cell types has proven challenging. Herein, we developed a prodrug strategy to design a new compound based on the increased activity of lysosomal β-galactosidase (β-gal), a primary characteristic of senescent cells. Our prodrug SSK1 is specifically activated by β-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types. In aged mice, our compound effectively cleared senescent cells in different tissues, decreased the senescence- and age-associated gene signatures, attenuated low-grade local and systemic inflammation, and restored physical function. Our results demonstrate that lysosomal β-gal can be effectively leveraged to selectively eliminate senescent cells, providing a novel strategy to develop anti-aging interventions.
has issue date	2020-04-27(xsd:dateTime)
bibo:doi	10.1038/s41422-020-0314-9
bibo:pmid	32341413
has license	cc-by
sha1sum (hex)	2b59b72c648e8a39f99b74719e621264c96b547f
schema:url	https://doi.org/10.1038/s41422-020-0314-9
resource representing a document's title	Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
has PubMed Central identifier	PMC7184167
has PubMed identifier	32341413
schema:publication	Cell Res
resource representing a document's body	covid:2b59b72c648e8a39f99b74719e621264c96b547f#body_text
is schema:about of	named entity 'organisms' named entity 'effectively' named entity 'anti-aging' named entity 'However' named entity 'aged' named entity 'senescent cells' named entity 'primary' named entity 'demonstrate' named entity 'β-gal' named entity 'attenuates' named entity 'ATTENUATED' named entity 'PROVEN' named entity 'NOVEL' named entity 'MOUSE' named entity 'PRIMARY' named entity 'SELECTIVE' named entity 'mice' named entity 'β-gal' named entity 'compound' named entity 'selective' named entity 'restored' named entity 'strategy' named entity 'aged' named entity 'senescence' named entity 'β-gal' named entity 'phenotypes' named entity 'lysosomal' named entity 'senescent cells' named entity 'mice' named entity 'senescent cells' named entity 'senescent cells' named entity 'inflammation' named entity 'prodrug' named entity 'β-galactosidase' named entity 'prodrug' named entity 'cell types' named entity 'mice' named entity 'lysosomal' named entity 'DESIGN' named entity 'AGE' named entity 'LYSOSOMAL' named entity 'AGED' named entity 'DRIVES' named entity 'SIGNATURES' named entity 'TISSUE' named entity 'STATE' named entity 'COMPOUND' named entity 'CLEARED' named entity 'ACTIVATED' named entity 'DECLINE' named entity 'LOW' named entity 'SYSTEMIC INFLAMMATION' named entity 'ORGANISMS' named entity 'physical function' named entity 'senescent cells' named entity 'senescent cells' named entity 'cell types' named entity 'senescence' named entity 'gene' named entity 'senescent cells' named entity 'β-galactosidase' covid:arg/2b59b72c648e8a39f99b74719e621264c96b547f named entity 'TISSUES' named entity 'INFLAMMATION' named entity 'DIFFERENT' named entity 'CHARACTERISTIC' named entity 'NEW' named entity 'GALACTOSIDASE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software