About: The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides
Creator	Lou, Xia Chirila, Traian Constable, Ian Garrett, Kerryn Rakoczy, Piroska
source	Elsevier; Medline; PMC
abstract	Abstract Developed over the past two decades, the antisense strategy has become a technology of recognised therapeutic potential, and many of the problems raised earlier in its application have been solved to varying extents. However, the adequate delivery of antisense oligodeoxynucleotides to individual cells remains an important and inordinately difficult challenge. Synthetic polymers appeared on this scene in the middle 1980s, and there is a surprisingly large variety used or proposed so far as agents for delivery of oligodeoxynucleotides. After discussing the principles of antisense strategy, certain aspects of the ingestion of macromolecules by cells, and the present situation of delivery procedures, this article analyses in detail the attempts to use synthetic polymers as carrier matrices and/or cell membrane permeabilisation agents for delivery of antisense oligodeoxynucleotides. Structural aspects of various polymers, as well as the results, promises and limitations of their use are critically evaluated.
has issue date	2002-01-31(xsd:dateTime)
bibo:doi	10.1016/s0142-9612(01)00125-9
bibo:pmid	11761152
has license	els-covid
sha1sum (hex)	2b6d180732c1857bfc8f5b724275c84c29cfc359
schema:url	https://doi.org/10.1016/s0142-9612%2801%2900125-9
resource representing a document's title	The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides
has PubMed Central identifier	PMC7124374
has PubMed identifier	11761152
schema:publication	Biomaterials
resource representing a document's body	covid:2b6d180732c1857bfc8f5b724275c84c29cfc359#body_text
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