About: Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs

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About: Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs
Creator	Santos, J Aoki, C Brunetto, M Carciofi, A Kroll, F Pedrinelli, V Putarov, T Vendramini, T Venturini, K Zaine, L
topic	covid:2b6ed90f4a98fc04c97fac3ba450f8ae76fb728f#this
Source	Elsevier; Medline; PMC
abstract	Abstract Nutritional intervention in older dogs aims to increase lifespan and improve life quality as well as delay the development of diseases related to ageing. It is believed that active fractions of mannoproteins (AFMs) obtained through extraction and fractionation of yeast cell walls (Saccharomyces cerevisiae) may beneficially modulate the immune system. However, studies that have evaluated this component and the effects of ageing on the immune system of dogs are scarce. This study aimed to evaluate the immunological effects of AFMs in adult and elderly dogs. Three extruded iso-nutrient experimental diets were formulated: without addition of AFM (T0); with AFM at 400 mg/kg (T400); and with AFM at 800 mg/kg (T800). Thirty-six beagle dogs were used, and six experimental treatments, resulting in combinations of age (adult and elderly) and diet (T0, T400, and T800), were evaluated. On days zero, 14, and 28, blood samples were obtained for leucocyte phenotyping and phagocytosis assays. On days zero and 28, a lymphoproliferation test, quantification of reactive oxygen (H2O2) and nitrogen (NO) intermediate production, evaluation of faecal immunoglobulin A (IgA) content, and a delayed cutaneous hypersensitivity test (DCHT) were performed. Statistical analyses were performed with SAS software. Repeated measure variance analyses were performed, and means were compared by the Tukey test. Values of P ≤ 0.05 were considered significant, and values of P ≤ 0.10 were considered tendencies. Dogs fed T400 tended to have higher neutrophilic phagocytic activity than dogs fed T800 (P = 0.073). Regarding reactive oxygen intermediates, bacterial lipopolysaccharide (LPS)-stimulated neutrophils from animals that were fed T400 had a tendency to produce more H2O2 than those from animals fed the control diet (P = 0.093). Elderly dogs, when compared to adult dogs, had lower absolute T and B lymphocyte counts, lower auxiliary T lymphocyte counts, and higher cytotoxic T lymphocyte counts (P < 0.05). A significant effect of diet, age, and time with saline inoculation was noted for the DCHT. There was no effect of diet or age on faecal IgA content in dogs. This study suggests beneficial effects of mannoproteins on the specific and nonspecific immune responses in adult and elderly dogs.
has issue date	2020-03-31(xsd:dateTime)
bibo:doi	10.1016/j.anifeedsci.2020.114392
bibo:pmid	32288071
has license	els-covid
sha1sum (hex)	2b6ed90f4a98fc04c97fac3ba450f8ae76fb728f
schema:url	https://doi.org/10.1016/j.anifeedsci.2020.114392
resource representing a document's title	Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs
has PubMed Central identifier	PMC7126846
has PubMed identifier	32288071
schema:publication	Animal Feed Science and Technology
resource representing a document's body	covid:2b6ed90f4a98fc04c97fac3ba450f8ae76fb728f#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/2b6ed90f4a98fc04c97fac3ba450f8ae76fb728f
is schema:about of	named entity 'control' named entity 'T lymphocyte' named entity 'hypersensitivity' named entity 'fed' named entity 'cutaneous' named entity 'diet' named entity 'intermediate' named entity 'diet' named entity 'cell walls' named entity 'yeast' named entity 'innate' named entity 'EVALUATED' named entity 'AIMS' named entity 'AGEING' named entity 'NUTRITIONAL INTERVENTION' named entity 'EXTRUDED' named entity 'TEST' named entity 'NOTED' named entity 'VALUES' named entity 'DOGS' named entity '28P' named entity 'MODULATE' named entity 'REPEATED' named entity 'FRACTIONS OF' named entity 'AGE' named entity 'NITROGEN' named entity 'ADDITION' named entity 'MEASURE' named entity 'EFFECTS' named entity 'STUDY' named entity 'BLOOD SAMPLES' named entity 'ELDERLY' named entity 'STATISTICAL ANALYSES' named entity 'STUDIES' named entity 'ACTIVITY' named entity 'EVALUATE' named entity 'USED' named entity 'IMMUNOGLOBULIN A' named entity 'ADULT' named entity 'ACTIVE' named entity 'CELL WALLS' named entity 'DELAYED CUTANEOUS HYPERSENSITIVITY' named entity 'HIGHER' named entity 'DISEASES' named entity 'NEUTROPHILIC' covid:arg/2b6ed90f4a98fc04c97fac3ba450f8ae76fb728f named entity 'FRACTIONS OF' named entity 'ADULT' named entity 'DERIVED' named entity 'SOFTWARE' named entity 'LOWER' named entity '800' named entity 'STIMULATED' named entity 'OBTAINED' named entity 'LIFESPAN' named entity '400' named entity 'DEVELOPMENT' named entity 'COMPONENT' named entity 'IMMUNOLOGICAL' named entity 'QUANTIFICATION' named entity 'TENDENCY' named entity 'HAVE' named entity 'CONTROL' named entity 'YEAST CELL' named entity 'LEUCOCYTE' named entity 'DELAY' named entity 'SAS' named entity 'ISO-' named entity 'BACTERIAL' named entity 'DCHT'

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