About: Utility of DNA Microarrays for Detection of Viruses in Acute Respiratory Tract Infections in Children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Utility of DNA Microarrays for Detection of Viruses in Acute Respiratory Tract Infections in Children
Creator	Urisman, Anatoly Wang, David Yagi, Shigeo Chiu, Charles Schnurr, David Wright, Carolyn Derisi, Joseph Drew, W Greenhow, Tara Weintrub, Peggy
Source	Elsevier; Medline; PMC
abstract	OBJECTIVE: To assess the utility of a pan-viral DNA microarray platform (Virochip) in the detection of viruses associated with pediatric respiratory tract infections. STUDY DESIGN: The Virochip was compared with conventional direct fluorescent antibody (DFA) and PCR-based testing for the detection of respiratory viruses in 278 consecutive nasopharyngeal aspirate samples from 222 children. RESULTS: The Virochip was superior in performance to DFA, showing a 19% increase in the detection of 7 respiratory viruses included in standard DFA panels, and was similar to virus-specific PCR (sensitivity 85–90%, specificity ≥99%, PPV 94–96%, NPV 97–98%) in the detection of respiratory syncytial virus, influenza A, and rhino-/enteroviruses. The Virochip also detected viruses not routinely tested for or missed by DFA and PCR, as well as double infections and infections in critically ill patients that DFA failed to detect. CONCLUSIONS: Given its favorable sensitivity and specificity profile and expanded spectrum for detection, microarray-based viral testing holds promise for clinical diagnosis of pediatric respiratory tract infections.
has issue date	2008-07-01(xsd:dateTime)
bibo:doi	10.1016/j.jpeds.2007.12.035
bibo:pmid	18571541
has license	green-oa
sha1sum (hex)	2b93e289e44efaa2a80abbe17c6985a7d833dc5a
schema:url	https://doi.org/10.1016/j.jpeds.2007.12.035
resource representing a document's title	Utility of DNA Microarrays for Detection of Viruses in Acute Respiratory Tract Infections in Children
has PubMed Central identifier	PMC3174048
has PubMed identifier	18571541
schema:publication	The Journal of Pediatrics
resource representing a document's body	covid:2b93e289e44efaa2a80abbe17c6985a7d833dc5a#body_text
is schema:about of	named entity 'Viruses' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'PEDIATRIC' named entity 'UTILITY' named entity 'ACUTE' named entity 'DETECTION' named entity 'OBJECTIVE' named entity 'MICROARRAY PLATFORM' named entity 'DNA MICROARRAY' named entity 'VIRUSES' named entity 'VIRUSES' named entity 'DNA MICROARRAYS' named entity 'DETECTION' named entity 'ASSESS' named entity 'CHILDREN' named entity 'UTILITY' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'ASSOCIATED WITH' covid:arg/2b93e289e44efaa2a80abbe17c6985a7d833dc5a named entity 'AdV' named entity 'microarrays' named entity 'microarrays' named entity 'immunocompromised state' named entity 'RNA' named entity 'Polymerase chain reaction' named entity 'virus' named entity 'Union City, California' named entity 'RSV' named entity 'virus' named entity 'DFA' named entity 'Valencia, California' named entity 'bacterial pathogens' named entity 'DFA' named entity 'RT-PCR' named entity 'infection' named entity 'microarray' named entity 'DFA' named entity 'microarray' named entity 'invasive procedures' named entity 'Temecula' named entity 'infection' named entity 'respiratory failure' named entity 'viruses' named entity 'pathogens' named entity 'emergency department' named entity 'aspiration pneumonia' named entity 'fever' named entity 'infection' named entity 'viral pathogens' named entity 'RNA' named entity 'DNA viruses' named entity 'multiplex PCR' named entity 'Direct fluorescent antibody' named entity 'Venn diagram' named entity 'clinical practice' named entity 'viruses' named entity 'outpatient' named entity 'microarray' named entity 'patient cohorts' named entity 'DFA' named entity 'RT-PCR' named entity 'clinical diagnosis' named entity 'Infections' named entity 'viruses' named entity 'Viruses' named entity 'picornaviruses' named entity 'Microarrays' named entity 'reproducibility' named entity 'fungi' named entity 'RSV' named entity 'RSV' named entity 'DNA microarray'

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