About: Beyond molecular tumor heterogeneity: protein synthesis takes control

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Beyond molecular tumor heterogeneity: protein synthesis takes control
Creator	Sonenberg, Nahum Castellvi, Josep Hümmer, Stefan Peg, Vicente Pelletier, Jerry Ramon Y Cajal, Santiago
Source	PMC
abstract	One of the daunting challenges facing modern medicine lies in the understanding and treatment of tumor heterogeneity. Most tumors show intra-tumor heterogeneity at both genomic and proteomic levels, with marked impacts on the responses of therapeutic targets. Therapeutic target-related gene expression pathways are affected by hypoxia and cellular stress. However, the finding that targets such as eukaryotic initiation factor (eIF) 4E (and its phosphorylated form, p-eIF4E) are generally homogenously expressed throughout tumors, regardless of the presence of hypoxia or other cellular stress conditions, opens the exciting possibility that malignancies could be treated with therapies that combine targeting of eIF4E phosphorylation with immune checkpoint inhibitors or chemotherapy.
has issue date	2018-02-21(xsd:dateTime)
bibo:doi	10.1038/s41388-018-0152-0
bibo:pmid	29463861
has license	cc-by-nc-nd
sha1sum (hex)	2ba882c9ddb5e9db8ebb0db536788bff66b67f14
schema:url	https://doi.org/10.1038/s41388-018-0152-0
resource representing a document's title	Beyond molecular tumor heterogeneity: protein synthesis takes control
has PubMed Central identifier	PMC5945578
has PubMed identifier	29463861
schema:publication	Oncogene
resource representing a document's body	covid:2ba882c9ddb5e9db8ebb0db536788bff66b67f14#body_text
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