About: Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients

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About: Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients
Creator	Nissen, Sloots, T Ferguson, Patricia Dwyer, D Sorrell, T Dwyer, T Ferguson, P Gilroy, N Nissen, D Sorrell,
Source	Medline; PMC
abstract	P.E. Ferguson, N.M. Gilroy, T.P. Sloots, M.D. Nissen, D.E. Dwyer, T.C. Sorrell. Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients. Transpl Infect Dis 2011: 13: 448–455. xx: 000–000. All rights reserved Abstract: A simple clinical screening (CS) tool for respiratory virus (RV) infection was introduced and evaluated in a single hematology ward, as part of a strategy to reduce nosocomial RV infection. Up to 6 clinical symptoms or signs were scored and a predefined threshold score of ≥2 prompted paired nose/throat swab (NTS) collection for RV testing. The criterion standard for RV infection was positive immunofluorescence (IF) or polymerase chain reaction (PCR) for 7 and 15 viruses, respectively. The tool was shown to be most beneficial at excluding infection at a threshold score of 1 (negative predictive value [NPV] 89%, [95% confidence interval 78–96%], sensitivity 85% [70–94%], specificity 35% [27–43%]), compared with a score of 2 (NPV 85% [76–91%], sensitivity 63% [46–77%], specificity 57% [48–65%]) at a prevalence of 22%. The tool's ability to diagnose infection was limited (positive predictive value 27% and 29% at thresholds 1 and 2). The sensitivity of IF compared with PCR was 45% for the 7 viruses common to both, and 23% for the extended virus panel detected by PCR. An algorithm incorporating CS, paired NTS collection at a threshold of 1 symptom or sign, and sensitive testing including PCR can guide infection control measures in hospitalized hematopoietic stem cell transplant recipients.
has issue date	2011-04-18(xsd:dateTime)
bibo:doi	10.1111/j.1399-3062.2011.00631.x
bibo:pmid	21501357
has license	no-cc
sha1sum (hex)	2bd5743e3df7c86642112d8bd971c6711888c767
schema:url	https://doi.org/10.1111/j.1399-3062.2011.00631.x
resource representing a document's title	Evaluation of a clinical scoring system and directed laboratory testing for respiratory virus infection in hematopoietic stem cell transplant recipients
has PubMed Central identifier	PMC7169734
has PubMed identifier	21501357
schema:publication	Transpl Infect Dis
resource representing a document's body	covid:2bd5743e3df7c86642112d8bd971c6711888c767#body_text
is schema:about of	named entity 'city' named entity 'Dis' named entity 'negative' named entity 'infection' named entity 'virus' named entity 'EVALUATION' named entity 'UP TO' named entity 'RESPIRATORY VIRUS' named entity 'COLLECTION' named entity 'NOSE' named entity 'DIRECTED' named entity 'ABSTRACT' named entity 'INTERVAL' named entity 'THRESHOLD' named entity 'RIGHTS' named entity 'CLINICAL SYMPTOMS' named entity 'respiratory' named entity 'score' named entity 'introduced' named entity 'screening' named entity 'The' named entity 'ward' named entity 'infection' named entity 'tool' named entity 'immuno' named entity '85%' named entity 'hematopoietic stem cell transplant' named entity 'infection' named entity 'laboratory testing' named entity 'viral burden' named entity 'real-time PCR' named entity 'teaching hospital' named entity 'PCR' named entity 'virological' named entity 'Infectious Diseases' named entity 'infection control' named entity 'LRTI' named entity 'aspirate' named entity 'infection' named entity 'PCR' named entity 'PCR testing' named entity 'infection control' named entity 'URTI' named entity 'hematology' named entity 'probability' named entity 'polymerase chain reaction' named entity 'hematology' named entity 'nasopharyngeal' named entity 'human embryonic' named entity 'physical examination' named entity 'infection' named entity 'bronchoalveolar lavage' named entity 'Fever' named entity 'clinical features' named entity 'HSCT' named entity 'LRTI' named entity 'autologous' named entity 'hematology' named entity 'HSCT' named entity 'RSV' named entity 'RVs' named entity 'clinical symptoms' named entity 'etiology' named entity 'nosocomial' named entity 'Clinical characteristics' named entity 'Rhinorrhea' named entity 'infection' named entity 'P-values' named entity 'human metapneumovirus' named entity 'post-test probability' named entity 'hematology' named entity 'California'

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