About: Structural model of the SARS coronavirus E channel in LMPG micelles

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About: Structural model of the SARS coronavirus E channel in LMPG micelles Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural model of the SARS coronavirus E channel in LMPG micelles
Creator	Li, Yan Surya, Wahyu Torres, Jaume
Source	Elsevier; Medline; PMC
abstract	Abstract Coronaviruses (CoV) cause common colds in humans, but are also responsible for the recent Severe Acute, and Middle East, respiratory syndromes (SARS and MERS, respectively). A promising approach for prevention are live attenuated vaccines (LAVs), some of which target the envelope (E) protein, which is a small membrane protein that forms ion channels. Unfortunately, detailed structural information is still limited for SARS-CoV E, and non-existent for other CoV E proteins. Herein, we report a structural model of a SARS-CoV E construct in LMPG micelles with, for the first time, unequivocal intermolecular NOEs. The model corresponding to the detergent-embedded region is consistent with previously obtained orientational restraints obtained in lipid bilayers and in vivo escape mutants. The C-terminal domain is mostly α-helical, and extramembrane intermolecular NOEs suggest interactions that may affect the TM channel conformation.
has issue date	2018-06-30(xsd:dateTime)
bibo:doi	10.1016/j.bbamem.2018.02.017
bibo:pmid	29474890
has license	els-covid
sha1sum (hex)	2c01b65a4468d43dad054457c80d05d5a2715ac6
schema:url	https://doi.org/10.1016/j.bbamem.2018.02.017
resource representing a document's title	Structural model of the SARS coronavirus E channel in LMPG micelles
has PubMed Central identifier	PMC7094280
has PubMed identifier	29474890
schema:publication	Biochimica et Biophysica Acta (BBA) - Biomembranes
resource representing a document's body	covid:2c01b65a4468d43dad054457c80d05d5a2715ac6#body_text
is schema:about of	named entity 'MERS' named entity 'vivo' named entity 'SARS CORONAVIRUS' named entity 'REPORT' named entity 'EMBEDDED' named entity 'LIMITED' named entity 'OBTAINED' named entity 'REGION' named entity 'C-TERMINAL' named entity 'INFORMATION' named entity 'CONSISTENT WITH' named entity 'PREVIOUSLY' named entity 'ACUTE' named entity 'DOMAIN' named entity 'COMMON COLDS' named entity 'PREVENTION' named entity 'SUGGEST' named entity 'HUMANS' named entity 'PROTEIN' named entity 'CONSTRUCT' named entity 'DETAILED' named entity 'MODEL OF' named entity 'SYNDROMES' named entity 'ESCAPE' named entity 'CORONAVIRUSES' named entity 'ION CHANNELS' named entity 'CAUSE' named entity 'SEVERE' named entity 'HELICAL' named entity 'IN VIVO' named entity 'MODEL OF' named entity 'RESPIRATORY' named entity 'AFFECT' named entity 'RESTRAINTS' named entity 'MERS' named entity 'SARS-COV' named entity 'MIDDLE EAST' named entity 'PROTEIN ' named entity 'RECENT' named entity 'IS A' named entity 'MUTANTS' named entity 'RESPONSIBLE' named entity 'TARGET' named entity 'DETERGENT' named entity 'NON-EXISTENT' named entity 'ENVELOPE' named entity 'BUT' named entity 'MICELLES' named entity 'STRUCTURAL MODEL' named entity 'CHANNEL' named entity 'TIME' named entity 'MICELLES' named entity 'MODEL' named entity 'SMALL' named entity 'APPROACH' named entity 'MEMBRANE PROTEIN' named entity 'EXTRAMEMBRANE' named entity 'PROTEINS' named entity 'S T' named entity 'STRUCTURAL MODEL' named entity 'STRUCTURAL' named entity 'CHANNEL' named entity 'INTERACTIONS' named entity 'CONFORMATION' named entity 'LIPID BILAYERS' named entity 'UNEQUIVOCAL' named entity 'FORMS' named entity 'LIVE' named entity 'ATTENUATED VACCINES' covid:arg/2c01b65a4468d43dad054457c80d05d5a2715ac6 named entity 'live attenuated vaccines' named entity 'time' named entity 'channel' named entity 'mutants' named entity 'conformation' named entity 'lipid' named entity 'responsible' named entity 'respiratory' named entity 'common colds'

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