About: Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025)

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025)
Creator	Ahmed-Belkacem, Abdelhakim Ahnou, Nazim Brillet, Rozenn Bruscella, Patrice Fourati, Slim Nevers, Quentin Pawlotsky, Jean-Michel Softic, Laurent Berry, François Hamadat, Sabah Morin-Dewaele, Margot
Source	Medline; PMC
abstract	Cyclophilins play a key role in the life cycle of coronaviruses. Alisporivir (Debio 025) is a nonimmunosuppressive analogue of cyclosporine with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in Vero E6 cells, with a 50% effective concentration (EC(50)) of 0.46 ± 0.04 μM. Alisporivir inhibited a postentry step of the SARS-CoV-2 life cycle. These results justify rapidly conducting a proof-of-concept phase 2 trial with alisporivir in patients with SARS-CoV-2 infection.
has issue date	2020-06-23(xsd:dateTime)
bibo:doi	10.1128/aac.00876-20
bibo:pmid	32376613
has license	no-cc
sha1sum (hex)	2c8d4e15e88c241d80e7699bbf74b7118fdaf2a9
schema:url	https://doi.org/10.1128/aac.00876-20
resource representing a document's title	Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025)
has PubMed Central identifier	PMC7318051
has PubMed identifier	32376613
schema:publication	Antimicrob Agents Chemother
resource representing a document's body	covid:2c8d4e15e88c241d80e7699bbf74b7118fdaf2a9#body_text
is schema:about of	named entity 'potent' named entity 'life cycle' named entity 'reduced' named entity 'effective concentration' named entity 'CYCLOPHILIN' named entity 'ROLE' named entity 'PLAY' named entity 'CYCLOSPORINE' named entity 'INHIBITED' covid:arg/2c8d4e15e88c241d80e7699bbf74b7118fdaf2a9 named entity 'manner' named entity 'inhibition' named entity 'Cyclophilins' named entity 'infection' named entity 'HCoV-229E' named entity 'MERS-CoV' named entity 'antiviral' named entity 'infection' named entity 'Vero E6 cells' named entity 'HCoV-NL63' named entity 'SARS-CoV-2' named entity 'antiviral' named entity 'pathogen' named entity 'proline' named entity 'antiviral effect' named entity 'COVID' named entity 'preclinical' named entity 'SARS-CoV-2' named entity 'dsRNA' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'coronaviruses' named entity 'monotherapy' named entity 'mouse hepatitis virus' named entity 'Middle East respiratory syndrome coronavirus' named entity 'RNA' named entity 'dose-dependent manner' named entity 'trans' named entity 'phase 2' named entity 'COVID' named entity 'infection' named entity 'cytotoxic' named entity 'clinical trial' named entity 'lopinavir' named entity 'phase 2' named entity 'cytotoxic' named entity 'COVID' named entity 'Vero E6' named entity 'viral RNA' named entity 'life cycle' named entity 'proof-of-concept' named entity 'Vero E6' named entity 'SARS-CoV-2' named entity 'antiviral' named entity 'MERS-CoV' named entity 'coronavirus disease 2019' named entity 'viral entry' named entity 'hepatitis C virus' named entity 'SARS-CoV-2' named entity 'chloroquine' named entity 'COVID' named entity 'CsA' named entity 'life cycle' named entity 'pharmacology' named entity 'Vero E6' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'antibody' named entity 'DMSO' named entity 'SARS-CoV' named entity 'antiviral' named entity 'Chloroquine'

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