About: A clustering of rna recombination sites adjacent to a hypervariable region of the peplomer gene of murine coronavirus

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About: A clustering of rna recombination sites adjacent to a hypervariable region of the peplomer gene of murine coronavirus Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A clustering of rna recombination sites adjacent to a hypervariable region of the peplomer gene of murine coronavirus
Creator	Banner, Lisa Keck,' And, James La12, Michael
Source	Elsevier; Medline; PMC
abstract	Abstract Coronaviruses undergo RNA recombination at a very high frequency. To understand the mechanism of recombination in murine coronavirus, we have performed RNA sequencing of viral genomic RNA to determine the precise sites of recombination in a series of recombinants which have crossovers within the gene encoding the peplomer protein. We found that all of the recombination sites are clustered within a region of 278 nucleotides in the 5′-half of the gene. This region in which all of the crossovers occurred represents a small fraction of the distance between the two selection markers used for the isolation of these recombinant viruses. This result suggests that this region may be a preferred site for RNA recombination. The crossover sites are located within and immediately adjacent to a hypervariable area of the gene. This area has undergone deletions of varying sizes in several virus strains which have been passaged either in vivo or in vitro. These results suggest that a similar RNA structure may be involved in the occurrence of both recombination and deletion events.
has issue date	1990-04-30(xsd:dateTime)
bibo:doi	10.1016/0042-6822(90)90439-x
bibo:pmid	2158184
has license	els-covid
sha1sum (hex)	2cc04b63c89fb7ef725ebd6bd7450d206e7f0e86
schema:url	https://doi.org/10.1016/0042-6822%2890%2990439-x
resource representing a document's title	A clustering of rna recombination sites adjacent to a hypervariable region of the peplomer gene of murine coronavirus
has PubMed Central identifier	PMC7130556
has PubMed identifier	2158184
schema:publication	Virology
resource representing a document's body	covid:2cc04b63c89fb7ef725ebd6bd7450d206e7f0e86#body_text
is schema:about of	named entity 'HYPERVARIABLE REGION' named entity 'VIRUSES' named entity 'RNA SEQUENCING' named entity 'MECHANISM' named entity 'RNA' named entity 'SELECTION MARKERS' named entity 'FOUND' named entity 'OCCURRED' named entity 'RECOMBINANTS' named entity 'DISTANCE' named entity 'RNA RECOMBINATION' named entity 'VIRAL' named entity 'SMALL' named entity 'recombination' named entity 'region' named entity 'RECOMBINANT' named entity 'RECOMBINATION' named entity 'GENE' named entity 'RNA RECOMBINATION' named entity 'CLUSTERING' named entity 'SITES' named entity 'THESE' named entity 'HALF' named entity 'GENE' named entity 'NUCLEOTIDES' named entity 'USED' named entity 'ENCODING' named entity 'SERIES' named entity 'PREFERRED' named entity 'HAVE' named entity 'UNDERSTAND' named entity 'ISOLATION' named entity 'MURINE CORONAVIRUS' named entity 'HIGH FREQUENCY' named entity 'MAY BE A' named entity 'FRACTION OF' named entity 'PRECISE' named entity 'DETERMINE' named entity 'MURINE CORONAVIRUS' named entity 'ADJACENT TO' named entity 'PERFORMED' named entity 'REGION' named entity 'PROTEIN' named entity 'GENOMIC' named entity 'SITE' named entity 'VERY HIGH' named entity 'SITES' named entity 'RESULT' named entity 'CLUSTERED' covid:arg/2cc04b63c89fb7ef725ebd6bd7450d206e7f0e86 named entity 'viral' named entity 'result' named entity 'crossovers' named entity 'site' named entity 'determine' named entity 'Gene' named entity 'recombinant' named entity 'RNA sequencing' named entity 'gene' named entity 'recombination' named entity 'recombination' named entity 'recombination' named entity 'recombinants' named entity 'Coronaviridae' named entity 'deletions' named entity 'viruses' named entity 'sucrose' named entity 'gene' named entity 'A59' named entity 'recombinants' named entity 'recombinants' named entity 'gene' named entity 'electrophoresed' named entity 'virion' named entity 'protein' named entity 'recombination' named entity 'RNA sequences' named entity 'mRNAs' named entity 'astrocytoma'

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