About: Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients

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About: Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients
Creator	Li, Weijia Chamorro-Pareja, Natalia Karamanis Phd, Dimitrios Kokkinidis, Damianos Mathias Md, Priyanka Palaiodimos, Leonidas Zavras, Phaedon
source	MedRxiv
abstract	Background: Infectious diseases are more frequent and can be associated with worse outcomes in patients with diabetes. Our aim was to systematically review and synthesize with a meta-analysis the available observational studies reporting the effect of diabetes in mortality among hospitalized patients with COVID-19. Methods: Medline, Embase, Google Scholar, and medRxiv databases were reviewed. A random-effect model meta-analysis was used and I-square was utilized to assess the heterogeneity. In-hospital mortality was defined as the endpoint. Sensitivity, subgroup, and meta-regression analyses were performed. Results: 18,506 patients were included in this meta-analysis (3,713 diabetics and 14,793 non-diabetics). Patients with diabetes were associated with a higher risk of death compared to patients without diabetes (OR: 1.65; 95% CI: 1.35, 1.96; I2 77.4%). The heterogeneity was high. A study level meta-regression analysis was performed for all the important covariates and no significant interactions were found between the covariates and the outcome of mortality. Conclusion: This meta-analysis shows that that the likelihood of death is 65% higher in diabetic hospitalized patients with COVID-19 compared to non-diabetics. Further studies are needed to assess whether this association is independent or not, as well as to investigate to role of glucose control prior or during the disease.
has issue date	2020-05-28(xsd:dateTime)
bibo:doi	10.1101/2020.05.26.20113811
has license	medrxiv
sha1sum (hex)	2cf10931839d6b8f4fa1951318866761cf2303a4
schema:url	https://doi.org/10.1101/2020.05.26.20113811
resource representing a document's title	Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients
resource representing a document's body	covid:2cf10931839d6b8f4fa1951318866761cf2303a4#body_text
is schema:about of	named entity 'systematic review' named entity 'systematic review' named entity 'Diabetes' named entity 'malignancy' named entity 'preprint' named entity 'preprint' named entity 'stroke' named entity 'peer review' named entity 'copyright holder' named entity 'preprint' named entity 'copyright holder' named entity 'preprint' named entity 'medRxiv' named entity 'medRxiv' named entity 'hypertension' named entity 'female sex' named entity 'heart failure' named entity 'copyright holder' named entity 'medRxiv' named entity 'preprint' named entity 'preprint' named entity 'preprint' named entity 'preprint' named entity 'preprint' named entity 'preprint' named entity 'CC-BY 4.0 International license' named entity 'CC-BY 4.0 International license' named entity 'preprint' named entity 'medRxiv' named entity 'preprint' named entity 'preprint' named entity 'coronary artery disease' named entity 'copyright holder' named entity 'preprint' named entity 'copyright holder' named entity 'copyright holder' named entity 'peer review' named entity 'medRxiv' named entity 'CC-BY 4.0 International license' named entity 'medRxiv' named entity 'copyright holder' named entity 'copyright holder' named entity 'medRxiv' named entity 'peer review' named entity 'preprint' named entity 'chronic kidney disease' named entity 'preprint' named entity 'CC-BY 4.0 International license' named entity 'copyright holder' named entity 'preprint' named entity 'COPD' named entity 'preprint' named entity 'meta-analysis' named entity 'regression analyses' named entity 'medRxiv' named entity 'medRxiv' named entity 'COVID-19' named entity 'IN-HOSPITAL MORTALITY' named entity 'DIABETES' named entity 'COVID-19' named entity 'PATIENTS' named entity 'patients' named entity 'patients' named entity 'mortality' named entity 'meta-analysis' named entity 'Diabetes' named entity 'COVID-19' named entity 'ASSOCIATED WITH' named entity 'META-ANALYSIS' named entity 'INCREASED RISK' named entity 'SYSTEMATIC REVIEW'
is part of of	Background: Infectious diseases are more frequent and can be associated with worse outcomes in patients with diabetes. Our aim was to systematically review and synthesize with a meta-analysis the available observational studies reporting the effect of diabetes in mortality among hospitalized patients with COVID-19. Methods: Medline, Embase, Google Scholar, and medRxiv databases were reviewed. A random-effect model meta-analysis was used and I-square was utilized to assess the heterogeneity. In-hospital mortality was defined as the endpoint. Sensitivity, subgroup, and meta-regression analyses were performed. Results: 18,506 patients were included in this meta-analysis (3,713 diabetics and 14,793 non-diabetics). Patients with diabetes were associated with a higher risk of death compared to patients without diabetes (OR: 1.65; 95% CI: 1.35, 1.96; I2 77.4%). The heterogeneity was high. A study level meta-regression analysis was performed for all the important covariates and no significant interactions were found between the covariates and the outcome of mortality. Conclusion: This meta-analysis shows that that the likelihood of death is 65% higher in diabetic hospitalized patients with COVID-19 compared to non-diabetics. Further studies are needed to assess whether this association is independent or not, as well as to investigate to role of glucose control prior or during the disease. covid:2cf10931839d6b8f4fa1951318866761cf2303a4#body_text Diabetes is associated with increased risk for in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis comprising 18,506 patients

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