About: Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit

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About: Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit
Creator	Ito, Takashi Kajiyama, Kenji Kakihana, Yasuyuki Maeda, Hiroyuki Yashima, Nozomi Ikuro Maruyama, &
Source	PMC
abstract	An abnormal elevation in pressure is a serious complication involving the extracorporeal circulation circuit. Clot formation might be associated with this complication, but the precise mechanism of an abnormal elevation in pressure has not been identified. We investigated sufficient conditions for in-circuit elevation in pressure using an ex vivo re-circulation circuit with porcine blood. Specifically, we investigated the effect of blood conditions, the type of anticoagulation, and pro-inflammatory stimulation on in-circuit pressure. We also examined the cause of an abnormal elevation of in-circuit pressure by specifically degrading DNA, RNA, or protein components of an obstructed filter and by using immunofluorescent techniques. Neither a change in temperature nor change in pH in the blood increased in-circuit pressure. In contrast, long-term storage of blood, pro-inflammatory stimulation by phorbol myristate acetate, and heparin administration significantly increased in-circuit pressure. Abnormal in-circuit elevation in pressure was associated with deposition of extracellular DNA on the outlet surface of the filter. Administration of DNase resulted in a rapid decline of in-circuit pressure. In an ex vivo re-circulation circuit system, extracellular DNA deposition on the filter is responsible for an abnormal in-circuit elevation in pressure. Senescent leukocytes, stimulated leukocytes, and heparin exposure are associated with extracellular DNA deposition.
has issue date	2020-01-16(xsd:dateTime)
bibo:doi	10.1038/s41598-019-57173-5
bibo:pmid	31949234
has license	cc-by
sha1sum (hex)	2cf9c120c360c2cfbafe7c855779e5270fa51509
schema:url	https://doi.org/10.1038/s41598-019-57173-5
resource representing a document's title	Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit
has PubMed Central identifier	PMC6965310
has PubMed identifier	31949234
schema:publication	Sci Rep
resource representing a document's body	covid:2cf9c120c360c2cfbafe7c855779e5270fa51509#body_text
is schema:about of	named entity 'deposition' named entity 'filter' named entity 'circuit' named entity 'immunofluorescent' named entity 'elevation' named entity 'porcine' named entity 'Administration' named entity 'EXAMINED' named entity 'EFFECT' named entity 'CHANGE IN' named entity 'SYSTEM' named entity 'RNA' named entity 'TEMPERATURE' named entity 'CIRCUIT' named entity 'INVESTIGATED' named entity 'STORAGE' named entity 'PRECISE' named entity 'FILTER' named entity 'DNA' named entity 'HEPARIN' named entity 'abnormal' named entity 'Neither' named entity 'filter' named entity 'complication' named entity 'mechanism' named entity 'formation' named entity 'temperature' named entity 'DNA' named entity 'Abnormal' named entity 'precise' named entity 'extracellular' named entity 'anticoagulation' named entity 'pro-inflammatory' named entity 'leukocytes' named entity 'immunofluorescent' named entity 'phorbol myristate acetate' named entity 'Leukocyte' named entity 'pressure' named entity 'cations' named entity 'Heparin' named entity 'intratracheal' named entity 'oxygenator' named entity 'heparin' named entity 'Giemsa' named entity 'PRP' named entity 'leukocytes' named entity 'leukocytes' named entity 'DNase' named entity 'NETosis' named entity 'ventilator-induced lung injury' named entity 'sodium citrate' named entity 'Cairo' named entity 'DNase' named entity 'leukocyte' named entity 'chelating' named entity 'leukocytes' named entity 'heparin' named entity 'NETs' named entity 'inflammatory response' named entity 'nature.com' named entity 'Heparin' named entity 'phorbol' named entity 'inflammatory' named entity 'EDTA' named entity 'manometer' named entity 'leukocyte' named entity 'leukocyte' named entity 'low temperature' named entity 'activated clotting time' named entity 'Amagasaki' named entity 'fibrin' named entity 'extracellular' named entity 'Japan' named entity 'Heparin' named entity '37 °C' named entity 'immunofluorescent'

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