About: Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model
Creator	Zhu, Z Dankmeyer, J Fast, R Wormald, M Xiao, X
Source	PMC
abstract	Yersinia pestis is the etiologic agent of plague that has killed more than 200 million people throughout the recorded history of mankind. Antibiotics may provide little immediate relief to patients who have a high bacteremia or to patients infected with an antibiotic resistant strain of plague. Two virulent factors of Y. pestis are the capsid F1 protein and the low-calcium response (Lcr) V-protein or V-antigen that have been proven to be the targets for both active and passive immunization. There are mouse monoclonal antibodies (mAbs) against the F1- and V-antigens that can passively protect mice in a murine model of plague; however, there are no anti-Yersinia pestis monoclonal antibodies available for prophylactic or therapeutic treatment in humans. We identified one anti-F1-specific human mAb (m252) and two anti-V-specific human mAb (m253, m254) by panning a naïve phage-displayed Fab library against the F1- and V-antigens. The Fabs were converted to IgG1s and their binding and protective activities were evaluated. M252 bound weakly to peptides located at the F1 N-terminus where a protective mouse anti-F1 mAb also binds. M253 bound strongly to a V-antigen peptide indicating a linear epitope; m254 did not bind to any peptide from a panel of 53 peptides suggesting that its epitope may be conformational. M252 showed better protection than m253 and m254 against a Y, pestis challenge in a plague mouse model. A synergistic effect was observed when the three antibodies were combined. Incomplete to complete protection was achieved when m252 was given at different times post-challenge. These antibodies can be further studied to determine their potential as therapeutics or prophylactics in Y. pestis infection in humans.
has issue date	2010-10-13(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0013047
bibo:pmid	20976274
has license	cc0
sha1sum (hex)	2d298d793c2521ceebdcd2c4be960591032ae0d3
schema:url	https://doi.org/10.1371/journal.pone.0013047
resource representing a document's title	Human Anti-Plague Monoclonal Antibodies Protect Mice from Yersinia pestis in a Bubonic Plague Model
has PubMed Central identifier	PMC2954148
has PubMed identifier	20976274
schema:publication	PLoS One
resource representing a document's body	covid:2d298d793c2521ceebdcd2c4be960591032ae0d3#body_text
is schema:about of	named entity 'MODEL' named entity 'HUMAN' named entity 'indicating' named entity 'located' named entity 'times' named entity 'PLAGUE' named entity 'ANTIBODIES' named entity 'HAVE' named entity 'ANTIGENS' named entity 'BOUND' named entity 'ETIOLOGIC AGENT' named entity 'PANNING' named entity 'VIRULENT' named entity 'THERAPEUTICS' named entity 'MODEL OF' named entity 'SPECIFIC' named entity 'FAB' named entity 'N-TERMINUS' named entity 'IDENTIFIED' named entity 'INDICATING' named entity 'THEIR' named entity 'PROTEIN ' named entity 'PESTIS' named entity 'PROTECTION' named entity 'EVALUATED' named entity 'GIVEN' named entity 'PASSIVE IMMUNIZATION' named entity 'AVAILABLE' named entity 'WHERE' named entity 'DISPLAYED' named entity 'HIGH' named entity 'RECORDED' named entity 'MICE' named entity 'DIFFERENT' named entity 'MAB' named entity 'INCOMPLETE' named entity 'LINEAR' named entity 'HUMAN' named entity 'ANTIBIOTIC RESISTANT STRAIN' named entity 'YERSINIA PESTIS' named entity 'BUBONIC PLAGUE' named entity 'MONOCLONAL ANTIBODIES' named entity 'MICE' named entity 'DID' named entity 'ANTIBIOTICS' named entity 'ACTIVE' named entity 'FABS' named entity 'PATIENTS' named entity 'MORE THAN' named entity 'INFECTION' named entity 'RELIEF' named entity 'COMBINED' named entity 'MILLION' named entity 'PEPTIDE' named entity '200' named entity 'INFECTED' named entity 'LIBRARY' named entity 'MONOCLONAL ANTIBODIES' named entity 'CALCIUM' named entity 'BETTER' named entity 'TREATMENT' named entity 'PROPHYLACTIC' named entity 'BINDING' named entity 'MOUSE' named entity 'DETERMINE' named entity 'BACTEREMIA' named entity 'PROVEN' named entity 'ANTIGEN' named entity 'PROVIDE' named entity 'HISTORY OF' named entity 'POTENTIAL' named entity 'CAPSID' named entity 'ANTIGEN PEPTIDE' named entity 'YERSINIA PESTIS' named entity 'ACTIVITIES' named entity 'MOUSE MODEL' named entity 'COMPLETE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software