About: Patient characteristics and severity of human rhinovirus infections in children

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About: Patient characteristics and severity of human rhinovirus infections in children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Patient characteristics and severity of human rhinovirus infections in children
Creator	Bangalore, Harish Tosas, Olga Tong, Aarons, Emma Bible, Jon Cheuk, Y Halligan, Eugene Lauinger, Ina Macmahon, Eithne
topic	covid:2d65775df0ad0ef808d79615f3f08a8bc030adc0#this
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: It is increasingly recognized that human rhinoviruses (HRV) can be associated with severe infections. However, conflicting results have been reported on the relative prevalence and severity of the three HRV species. OBJECTIVES: The relative prevalence and clinical characteristics of HRV-A, B and C, in children attending a South London teaching hospital were investigated retrospectively. STUDY DESIGN: Children aged <16 years with episodes of respiratory tract infections and detectable entero/rhinovirus RNA in respiratory samples between November 2009 and December 2010 were investigated. Retrospective case review was performed and patients’ characteristics recorded. RESULTS: Entero/rhinoviruses were the commonest viral pathogens (498/2316; 21.5%). Amongst 204 infection episodes associated with entero/rhinovirus, 167 were typed HRV, HRV-C was the most prevalent (99/167, 59.3%) followed by HRV-A (60/167; 35.9%) and HRV-B (8/167, 4.8%). The severity spectrum of HRV-A and HRV-C infections were similar and affected all parts of the respiratory tract. Co-pathogens were observed in 54 (26.5%) episodes. Severity was increased in patients with non-viral co-pathogens and those with an underlying respiratory condition. Univariate and multiple regression analyses of potential prognostic variables including age, co-pathogens and underlying respiratory illnesses showed that mono-infection with HRV-C, as compared with other HRV species, was associated with more severe disease in young children <3 years. CONCLUSIONS: HRV-C was the most prevalent species and on its own was associated with severe disease in children <3 years. The association between infection with HRV species and clinical presentation is complex and affected by many confounding factors.
has issue date	2013-07-22(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2013.06.042
bibo:pmid	23886500
has license	no-cc
sha1sum (hex)	2d65775df0ad0ef808d79615f3f08a8bc030adc0
schema:url	https://doi.org/10.1016/j.jcv.2013.06.042
resource representing a document's title	Patient characteristics and severity of human rhinovirus infections in children
has PubMed Central identifier	PMC7108361
has PubMed identifier	23886500
schema:publication	J Clin Virol
resource representing a document's body	covid:2d65775df0ad0ef808d79615f3f08a8bc030adc0#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/2d65775df0ad0ef808d79615f3f08a8bc030adc0
is schema:about of	named entity 'viral pathogens' named entity 'episodes' named entity 'episodes' named entity 'respiratory' named entity 'infections' named entity '2860' named entity 'CHILDREN' named entity 'RNA' named entity 'ASSOCIATION' named entity 'PREVALENCE' named entity 'INFECTIONS' named entity 'AGE' named entity '4.8' named entity 'CONFLICTING' named entity 'POTENTIAL' covid:arg/2d65775df0ad0ef808d79615f3f08a8bc030adc0 named entity 'REGRESSION ANALYSES' named entity 'ITS' named entity 'EPISODES' named entity 'DECEMBER' named entity 'RESPIRATORY TRACT' named entity 'HRV' named entity 'FOLLOWED BY' named entity 'RELATIVE' named entity 'MONOINFECTION' named entity 'CONFOUNDING FACTORS' named entity 'LONDON' named entity 'NOVEMBER' named entity '204' named entity '2899' named entity 'TEACHING HOSPITAL' named entity 'REPORTED' named entity 'RHINOVIRUSES' named entity 'SIMILAR' named entity 'STUDY DESIGN' named entity 'SOUTH' named entity 'INFECTIONS' named entity 'VIRAL PATHOGENS' named entity 'YEARS' named entity 'SPECIES' named entity 'PERFORMED' named entity 'RETROSPECTIVE' named entity 'RESPIRATORY' named entity 'PATIENT CHARACTERISTICS' named entity 'SEVERITY' named entity 'REVIEW' named entity 'COMPLEX' named entity 'CONCLUSIONS' named entity 'MULTIPLE REGRESSION' named entity 'PATHOGENS' named entity 'OBJECTIVES' named entity 'CHILDREN' named entity 'PARTS' named entity 'CHARACTERISTICS' named entity 'CLINICAL PRESENTATION' named entity 'INCLUDING' named entity 'VARIABLES' named entity 'INCREASED' named entity 'HUMAN RHINOVIRUS' named entity 'SEVERE' named entity 'HUMAN' named entity 'SPECTRUM' named entity 'SEVERE DISEASE' named entity 'ILLNESSES' named entity 'CASE' named entity '167' named entity 'RECORDED' named entity 'INFECTION' named entity 'CLINICAL CHARACTERISTICS' named entity 'ASSOCIATED WITH' named entity 'ATTENDING'

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