About: Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection

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About: Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection
Creator	Letko, Michael Munster, Vincent Scott, Dana Bowen, Richard Adney, Danielle Van Doremalen, Neeltje Ragan, Izabela
Source	Medline; PMC
abstract	In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%. Epidemiological investigations identified dromedary camels as the source of MERS-CoV zoonotic transmission and evidence of MERS-CoV circulation has been observed throughout the original range of distribution. Other new-world camelids, alpacas and llamas, are also susceptible to MERS-CoV infection. Currently, it is unknown whether Bactrian camels are susceptible to infection. The distribution of Bactrian camels overlaps partly with that of the dromedary camel in west and central Asia. The receptor for MERS-CoV, DPP4, of the Bactrian camel was 98.3% identical to the dromedary camel DPP4, and 100% identical for the 14 residues which interact with the MERS-CoV spike receptor. Upon intranasal inoculation with 107 plaque-forming units of MERS-CoV, animals developed a transient, primarily upper respiratory tract infection. Clinical signs of the MERS-CoV infection were benign, but shedding of large quantities of MERS-CoV from the URT was observed. These data are similar to infections reported with dromedary camel infections and indicate that Bactrians are susceptible to MERS-CoV and given their overlapping range are at risk of introduction and establishment of MERS-CoV within the Bactrian camel populations.
has issue date	2019-05-23(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1618687
bibo:pmid	31119984
has license	cc-by
sha1sum (hex)	2d73c30f41bb0fd24d5ddf1e71a472d971ce4d6f
schema:url	https://doi.org/10.1080/22221751.2019.1618687
resource representing a document's title	Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection
has PubMed Central identifier	PMC6534258
has PubMed identifier	31119984
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:2d73c30f41bb0fd24d5ddf1e71a472d971ce4d6f#body_text
is schema:about of	named entity 'EXPERIMENTAL INFECTION' named entity 'LARGE' named entity 'Bactrians' named entity 'central Asia' named entity 'MERS-CoV' named entity 'Middle East respiratory syndrome' covid:arg/2d73c30f41bb0fd24d5ddf1e71a472d971ce4d6f named entity 'INTRODUCTION' named entity 'UPPER RESPIRATORY TRACT INFECTION' named entity 'ORIGINAL' named entity '100%' named entity 'MORE THAN' named entity 'DATA' named entity 'SHEDDING' named entity 'EVIDENCE OF' named entity 'ESTABLISHMENT' named entity 'DATE' named entity 'EPIDEMIOLOGICAL' named entity 'CENTRAL ASIA' named entity 'WORLD' named entity 'PLAQUE-FORMING UNITS' named entity 'INFECTION' named entity 'APPROXIMATE' named entity 'THESE' named entity 'BENIGN' named entity 'BACTRIAN CAMEL' named entity 'AT RISK' named entity 'OVERLAPPING' named entity 'IDENTICAL' named entity 'INFECTIONS' named entity 'DISTRIBUTION' named entity 'SOURCE' named entity 'UNKNOWN' named entity 'RECEPTOR' named entity 'QUANTITIES' named entity 'CURRENTLY' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity '107' named entity 'INVESTIGATIONS' named entity 'RANGE' named entity 'INTRANASAL INOCULATION' named entity 'CAMELS' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'BUT' named entity 'THEIR' named entity 'HAVE' named entity 'SIMILAR' named entity 'RISK OF' named entity 'TRANSIENT' named entity 'SPIKE' named entity 'NEW' named entity 'GIVEN' named entity 'QUANTITIES' named entity 'ANIMALS' named entity 'CAMELS' named entity 'CASE FATALITY RATE' named entity 'DROMEDARY CAMEL' named entity 'OBSERVED' named entity 'POPULATIONS' named entity 'LLAMAS' named entity 'DPP4' named entity 'ALPACAS' named entity 'INTERACT' named entity 'LARGE' named entity 'CASES' named entity 'SUSCEPTIBLE' named entity 'DROMEDARY' named entity 'ZOONOTIC' named entity 'WEST' named entity 'CIRCULATION' named entity 'REPORTED' named entity 'IDENTIFIED' named entity 'TRANSMISSION' named entity 'OVERLAPS' named entity 'camel'

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