About: Mechanical ventilation utilization in COVID-19: A systematic review and meta-analysis

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanical ventilation utilization in COVID-19: A systematic review and meta-analysis
Creator	Parekh, Dhruv Sapey, Elizabeth Al Asmri, Mansour Alenezi, Farhan Alhuthail, Eyas Almeshari, Mohammed Alobaidi, Nowaf Alshehri, Ziyad
Source	MedRxiv
abstract	Background: In December 2019, SARS-CoV-2 caused a global pandemic with a viral infection called COVID19. The disease usually causes respiratory symptoms but in a small proportion of patients can lead to pneumonitis, Adult Respiratory Distress Syndrome and death. Invasive Mechanical Ventilation (IMV) is considered a life-saving treatment for COVID19 patients and a huge demand for IMV devices was reported globally. This review aims to provide insight into the initial IMV practices for COVID19 patients in the initial phase of the pandemic. Methods: Electronic databases (Embase and MEDLINE) were searched for applicable articles using relevant keywords. The references of included articles were hand searched. Articles that reported the use of IMV in adult COVID19 patients were included in the review. The NIH quality assessment tool for cohort and cross-sectional studies was used to appraise studies. Results: 106 abstracts were identified from the databases search, of which 16 were included. 5 studies were included in the meta-analysis. In total, 9988 patients were included across all studies. The overall cases of COVID-19 requiring IMV ranged from 2-77%. Increased age and pre-existing comorbidities increased the likelihood of IMV requirement. The reported mortality rate in patients receiving IMV ranged between 50-100%. On average, IMV was required and initiated between 10-17 days from symptoms onset. When ventilated, COVID19 patients required IMV for a median of 10-17 days across studies. Little information was provided on ventilatory protocols or management strategies. Conclusion: In these initial reporting studies for the first month of the pandemic, patients receiving IMV were older and had more pre-existing co-morbidities than those who did not require IMV. The mortality rate was high in COVID19 patients who received IMV. Studies are needed to evaluate protocols and modalities of IMV to improve outcomes and identify the populations most likely to benefit from IMV.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1101/2020.06.04.20122069
has license	medrxiv
sha1sum (hex)	2e1b093c7ce2e8491da167a8c983414d5817221d
schema:url	https://doi.org/10.1101/2020.06.04.20122069
resource representing a document's title	Mechanical ventilation utilization in COVID-19: A systematic review and meta-analysis
resource representing a document's body	covid:2e1b093c7ce2e8491da167a8c983414d5817221d#body_text
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