About: The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

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About: The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
Creator	Peiris, Malik Lim, Wilina Ng, Man Au, K Chan, Eric Chow, Eudora Hing, Wilfred Hk;, -H98083405@hkusua Hk;, -Whswong@hkucc Hk;, Ng -Ivy_Natsu@yahoo Hoi, Gloria Ip, Wk Ka, Helen Lau, Yu Law, Wai Po, Wai Tso, Wan Wai, Helen Wai, Man Wh, Raymond Wong, Sang
Source	Medline; PMC
abstract	BACKGROUND: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). METHODS: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. RESULTS: IFN-γ +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. CONCLUSION: IFN-γ +874A allele was shown to be a risk factor in SARS susceptibility.
has issue date	2006-05-04(xsd:dateTime)
bibo:doi	10.1186/1471-2334-6-82
bibo:pmid	16672072
has license	cc-by
sha1sum (hex)	2e2de8d6ebd368c062fed5770aa26a780bdc25b8
schema:url	https://doi.org/10.1186/1471-2334-6-82
resource representing a document's title	The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
has PubMed Central identifier	PMC1468415
has PubMed identifier	16672072
schema:publication	BMC Infect Dis
resource representing a document's body	covid:2e2de8d6ebd368c062fed5770aa26a780bdc25b8#body_text
is schema:about of	named entity 'severe acute respiratory syndrome' named entity 'CYTOKINES' named entity 'ANTIVIRAL ACTION' named entity 'IFN' named entity 'ROLES' named entity 'POLYMORPHISMS' named entity 'AFFECT' named entity 'IMPORTANT' named entity 'GENE POLYMORPHISM' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'BMC' named entity 'INTERFERON GAMMA ' named entity 'INFECTIOUS DISEASES' named entity 'BACKGROUND' named entity 'IL-10' named entity 'EXAMINED' named entity 'PLAY' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'OUTCOME' named entity 'ASSOCIATED WITH' named entity 'SUSCEPTIBILITY' covid:arg/2e2de8d6ebd368c062fed5770aa26a780bdc25b8 named entity 'Cytokines' named entity 'BMC Infectious Diseases' named entity 'SARS' named entity 'IFN-γ' named entity 'interferon gamma' named entity 'severe acute respiratory syndrome' named entity 'leukocytes' named entity 'genotyped' named entity 'allele' named entity 'polymorphisms' named entity '95% CI' named entity 'IL-10' named entity 'Interleukin 10' named entity '95% CI' named entity 'SARS' named entity 'IFN-γ' named entity 'prognosis' named entity 'tuberculosis' named entity 'MBL' named entity 'cytokine' named entity 'effector' named entity 'antiinflammatory' named entity 'chemokines' named entity 'Cytokines' named entity 'microbes' named entity 'CLEC4M' named entity 'pathogenesis' named entity 'allele' named entity 'correlation' named entity 'polymorphism' named entity 'Interferon' named entity 'inflammation' named entity 'macrophages' named entity 'infectious diseases' named entity 'serum' named entity 'mannose-binding lectin' named entity 'IL-10' named entity 'TNF-α' named entity 'SARS'

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