About: Risk factors for multidrug-resistant pathogens in bronchiectasis exacerbations

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Risk factors for multidrug-resistant pathogens in bronchiectasis exacerbations
Creator	Menéndez, Rosario Torres, Antoni Alcaraz, Victoria Amara-Elori, Isabel Fernández-Barat, Laia Méndez, Raúl Polverino, Eva Reyes, Soledad Rosales-Mayor, Edmundo Sahuquillo-Arce, José
Source	PMC
abstract	BACKGROUND: Non-cystic fibrosis bronchiectasis is a chronic structural lung condition that courses with recurrent infectious exacerbations that lead to frequent antibiotic treatment making this population more susceptible to acquire pathogens with antibiotic resistance. We aimed to investigate risk factors associated with isolation of multidrug-resistant pathogens in bronchiectasis exacerbations. METHODS: A prospective observational study was conducted in two tertiary-care hospitals, enrolling patients when first exacerbation appeared. Multidrug-resistance was determined according to European Centre of Diseases Prevention and Control classification. RESULTS: Two hundred thirty three exacerbations were included and microorganisms were isolated in 159 episodes. Multidrug-resistant pathogens were found in 20.1% episodes: Pseudomonas aeruginosa (48.5%), methicillin-resistant Staphylococcus aureus (18.2%) and Extended spectrum betalactamase + Enterobacteriaceae (6.1%), and they were more frequent in exacerbations requiring hospitalization (24.5% vs. 10.2%, p: 0.016). Three independent multidrug-resistant risk factors were found: chronic renal disease (Odds ratio (OR), 7.60, 95% CI 1.92–30.09), hospitalization in the previous year (OR, 3.88 95% CI 1.37–11.02) and prior multidrug-resistant isolation (OR, 5.58, 95% CI 2.02–15.46). The proportion of multidrug-resistant in the 233 exacerbations was as follows: 3.9% in patients without risk factors, 12.6% in those with 1 factor and 53.6% if ≥2 risk factors. CONCLUSIONS: Hospitalization in the previous year, chronic renal disease, and prior multidrug-resistant isolation are risk factors for identification multidrug-resistant pathogens in exacerbations. This information may assist clinicians in choosing empirical antibiotics in daily clinical practice.
has issue date	2017-09-30(xsd:dateTime)
bibo:doi	10.1186/s12879-017-2754-5
bibo:pmid	28964261
has license	cc-by
sha1sum (hex)	2e8855a1b4fa41526eac0e93264c024aef7f6c9d
schema:url	https://doi.org/10.1186/s12879-017-2754-5
resource representing a document's title	Risk factors for multidrug-resistant pathogens in bronchiectasis exacerbations
has PubMed Central identifier	PMC5622549
has PubMed identifier	28964261
schema:publication	BMC Infect Dis
resource representing a document's body	covid:2e8855a1b4fa41526eac0e93264c024aef7f6c9d#body_text
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