About: Prognostic role of serum high mobility group box 1 concentration in cardiac surgery

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prognostic role of serum high mobility group box 1 concentration in cardiac surgery
Creator	Jun, Ji-Hae Kim, Namo Kwak, Young-Lan Lee, Jeong-Rim Lee, Sak Shim, Jae-Kwang
Source	PMC
abstract	Outcomes of cardiac surgery are influenced by systemic inflammation. High mobility group box 1 (HMGB1), a pivotal inflammatory mediator, plays a potential role as a prognostic biomarker in cardiovascular disease. The aim of this prospective, observational study was to investigate the relationship between serum HMGB1 concentrations and composite of morbidity endpoints in cardiac surgery. Arterial blood samples for HMGB1 measurement were collected from 250 patients after anaesthetic induction (baseline) and 1 h after weaning from cardiopulmonary bypass (post-CPB). The incidence of composite of morbidity endpoints (death, myocardial infarction, stroke, renal failure and prolonged ventilator care) was compared in relation to the tertile distribution of serum HMGB1 concentrations. The incidence of composite of morbidity endpoints was significantly different with respect to the tertile distribution of post-CPB HMGB1 concentrations (p = 0.005) only, and not to the baseline. Multivariable analysis revealed post-CPB HMGB1 concentration (OR, 1.072; p = 0.044), pre-operative creatinine and duration of CPB as independent risk factors of adverse outcome. Accounting for its prominent role in mediating sterile inflammation and its relation to detrimental outcome, HMGB1 measured 1 h after weaning from CPB would serve as a useful biomarker for accurate risk stratification in cardiac surgical patients and may guide tailored anti-inflammatory therapy.
has issue date	2020-04-14(xsd:dateTime)
bibo:doi	10.1038/s41598-020-63051-2
bibo:pmid	32286371
has license	cc-by
sha1sum (hex)	2e8c3862afecfb92067189a7e3e316ae2b1022ba
schema:url	https://doi.org/10.1038/s41598-020-63051-2
resource representing a document's title	Prognostic role of serum high mobility group box 1 concentration in cardiac surgery
has PubMed Central identifier	PMC7156763
has PubMed identifier	32286371
schema:publication	Sci Rep
resource representing a document's body	covid:2e8c3862afecfb92067189a7e3e316ae2b1022ba#body_text
is schema:about of	named entity 'adverse outcome' named entity 'sterile' named entity 'inflammatory mediator' named entity 'mediating' named entity 'measurement' named entity 'Accounting' named entity 'cardiac surgery' named entity 'COLLECTED' named entity 'ACCOUNTING' named entity 'ROLE' named entity 'DIFFERENT' named entity 'POST' named entity 'CONCENTRATION' named entity 'INDEPENDENT' named entity 'induction' named entity 'collected' named entity 'patients' named entity 'HMGB1' named entity 'HMGB1' named entity 'respect' named entity 'systemic inflammation' named entity 'risk stratification' named entity 'tailored' named entity 'cardiopulmonary bypass' named entity 'renal failure' named entity 'odds ratio' named entity 'HMGB1' named entity 'guide' named entity 'endpoints' named entity 'potential' named entity 'baseline' named entity 'tertile' named entity 'measured' named entity 'therapy' named entity 'weaning' named entity 'cardiac surgery' named entity 'risk stratification' named entity 'serum' named entity 'ventilator' named entity 'morbidity' named entity 'systemic inflammation' named entity 'morbidity' named entity 'blood samples' named entity 'anti-inflammatory' named entity 'weaning' named entity 'HMGB1' named entity 'creatinine' named entity 'epinephrine' named entity 'congestive heart failure' named entity 'multivariable analysis' named entity 'cardiac surgery' named entity '2.0' named entity 'anti-inflammatory' named entity 'pulmonary artery catheter' named entity 'creatinine' named entity 'cardiovascular events' named entity 'HMGB1' named entity 'blood samples' named entity 'HMGB1' named entity 'transfusion' named entity 'HMGB1' named entity 'disease processes' named entity 'cell salvage' named entity 'milrinone' named entity 'serum' named entity 'weaning' named entity 'ng/mL' named entity 'reperfusion injury' named entity 'dobutamine' named entity 'mmHg' named entity 'morbidity' named entity 'sample size' named entity 'ventilator' named entity 'morbidity' named entity 'infusion' named entity 'Transfusion'

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