About: Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine

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About: Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine
Creator	Chen, Yu Liu, Bin Chen, Yue Chen, Yan Jin, Yinghua Zhou, Xianfeng Kong, Wei Liu, Junqiu Shan, Yaming Shen, Jiacong Wang, Xueyun Wu, Yongge Yu, Xianghui Zha, Xiao Zhang, Xizhen
Source	Elsevier; Medline; PMC
abstract	Abstract A novel approach involving the preparation of mannose-bearing chitosan microspheres with entrapping complexes of HBV DNA and PEI was developed to improve the delivery of DNA into antigen-presenting cells (APCs) after intramuscular (i.m.) injection. Compared with the traditional chitosan microspheres, the microspheres could quickly release intact and penetrative PEI/DNA complexes. What's more, chitosan was modified with mannose to target the primary APCs such as dendritic cells (DCs) owing to the high density of mannose receptors expressing on the surface of immature DCs. After i.m. immunization, the microspheres induced significantly enhanced serum antibody and cytotoxic T lymphocyte (CTL) responses in comparison to naked DNA.
has issue date	2007-08-28(xsd:dateTime)
bibo:doi	10.1016/j.jconrel.2007.05.018
bibo:pmid	17630014
has license	els-covid
sha1sum (hex)	2ec2eda2e464f9c1f36c8442410da77d23d87708
schema:url	https://doi.org/10.1016/j.jconrel.2007.05.018
resource representing a document's title	Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine
has PubMed Central identifier	PMC7126484
has PubMed identifier	17630014
schema:publication	Journal of Controlled Release
resource representing a document's body	covid:2ec2eda2e464f9c1f36c8442410da77d23d87708#body_text
is schema:about of	named entity 'MANNOSE' named entity 'immunization' named entity 'intramuscular' named entity 'CTL' named entity 'HBV' named entity 'chitosan' named entity 'CONTROLLED RELEASE' named entity 'WHAT' named entity 'PREPARATION' named entity 'COMPARED' named entity 'APPROACH' named entity 'MICROSPHERES' named entity 'INTACT' named entity 'SERUM' named entity 'CHITOSAN' named entity 'DELIVERY' covid:arg/2ec2eda2e464f9c1f36c8442410da77d23d87708 named entity 'DNA' named entity 'MODIFIED' named entity 'DELIVERY SYSTEM' named entity 'CHITOSAN' named entity 'BEARING' named entity 'IMMUNE RESPONSE' named entity 'HBV DNA' named entity 'PEI' named entity 'IMMATURE' named entity 'INTRAMUSCULAR' named entity 'PEI' named entity 'ENHANCED' named entity 'DCS' named entity 'ANTIGEN-PRESENTING CELLS' named entity 'HBV DNA' named entity '28I' named entity 'NOVEL' named entity 'TRADITIONAL' named entity 'INJECTION' named entity 'COMPLEXES' named entity 'ENHANCE' named entity 'DNA VACCINE' named entity 'RESPONSE TO' named entity 'MICROSPHERES' named entity 'CYTOTOXIC T LYMPHOCYTE' named entity 'SURFACE' named entity 'NAKED DNA' named entity 'TARGET' named entity 'PRIMARY' named entity 'INDUCED' named entity 'RESPONSES' named entity 'HIGH DENSITY' named entity 'INVOLVING' named entity 'DENDRITIC CELLS' named entity 'MANNOSE' named entity 'ANTIBODY' named entity 'COMPARISON' named entity 'IMMUNIZATION' named entity 'APCS' named entity 'RELEASE' named entity 'BEARING' named entity 'COMPLEXES' named entity '27S' named entity 'microspheres' named entity 'traditional' named entity 'After' named entity 'size distribution' named entity 'epitope' named entity 'D-glucosamine' named entity 'rhesus macaques'

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