About: Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China

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About: Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China
Creator	Ma, J Yang, P Li, C Chen, Z Chen, • Huang, • Jiang, Á Li, X Li, • Liu, J Liu, • Pang, X Peng, • Shu, Y Wang, Q Wang, • Zhang, Y Zhang, • Zheng, Y Wang, Á Cheng, • Lu, • Yang, • Deng, Y Jiang, • Li, Á Yang, Á Zeng, • Chen, Á Cheng, Á Huang, Á Jiao, Á Jiao, • Lu, Á Ma, • Pang, • Peng, Á Shu, • Song, R Zeng, Á Zheng, Á
source	PMC
abstract	PURPOSE: Human infections with avian influenza A (H7N9) virus manifested in China in March 2013. The first case infected with H7N9 virus in Beijing involved a family member of a chicken dealer and was reported in April 2013. The clinical and epidemiological characteristics of this case and her parents were examined to illustrate some key traits regarding this novel H7N9 virus. METHODS: The index case was subjected to intensive clinical examination in order to observed the clinical process. Real-time PCR was used to confirm cases infected with H7N9 virus. The index case was administered oseltamivir (45 mg, twice daily) at the early stage of the infection. Sera were collected from the index case and her parents from the onset of illness onwards. The subjects were followed for 4 weeks. RESULTS: The sera were confirmed by neutralizing antibody tests. The index case’s clinical manifestation progressed quickly. The pharyngeal swab tested positive for influenza A based on the detection of influenza A antigen (rapid influenza diagnostic test) 15 h after the onset of fever and was positive for H7N9 virus. The patient’s temperature dropped to 36.2 °C 18 h after treatment by oseltamivir (32 h after fever). Cough and other symptoms alleviated rapidly. A number of specimens from the environment of this cluster and from the feces specimens tested positive for viral RNA of the H7N9 virus on the fourth day following onset of the index case’s illness. Pharyngeal swabs of the mother tested positive for H7N9 virus twice, but she showed no clinical symptoms. Four weeks after disease onset, the family did not present any clinical symptoms, and the results of the physical examination and blood tests were normal. The mother and the case’s sera had a fourfold increased neutralizing antibody titer. CONCLUSION: Early diagnosis and early initiation of the treatment of confirmed infections is the most effective strategy for managing H7N9 virus infection. Human beings exposed to H7N9 virus may develop asymptomatic infection.
has issue date	2013-10-16(xsd:dateTime)
bibo:doi	10.1007/s15010-013-0533-9
bibo:pmid	24129555
has license	no-cc
sha1sum (hex)	2f33c5ab9f64e046ed247d8db9984349cd24a2a9
schema:url	https://doi.org/10.1007/s15010-013-0533-9
resource representing a document's title	Surveillance of the first case of human avian influenza A (H7N9) virus in Beijing, China
has PubMed Central identifier	PMC7102393
has PubMed identifier	24129555
schema:publication	Infection
resource representing a document's body	covid:2f33c5ab9f64e046ed247d8db9984349cd24a2a9#body_text
is schema:about of	named entity 'chicken' named entity 'case' named entity 'stage' named entity 'avian influenza' named entity 'H7N9' named entity 'order' named entity 'family' named entity 'H7N9' named entity 'member' named entity 'virus' named entity 'index case' named entity 'oseltamivir' named entity 'index case' named entity 'Beijing' named entity 'avian influenza' named entity 'H7N9' named entity 'antibodies' named entity 'H7N9' named entity 'virus' named entity 'PCR' named entity 'Influenza' named entity 'blood tests' named entity 'H7N9' named entity 'asymptomatic' named entity 'H7N9' named entity 'H7N9' named entity 'neutralizing antibodies' named entity 'rapid influenza diagnostic test' named entity 'acetaminophen' named entity 'virus infection' named entity 'H7N9' named entity 'infection' named entity 'high fever' named entity 'viruses' named entity 'ARDS' named entity 'Cough' named entity 'breath sounds' named entity 'antigens' named entity 'influenza' named entity 'gene' named entity 'chicken'

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