About: Kidney disease is associated with in-hospital death of patients with COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Kidney disease is associated with in-hospital death of patients with COVID-19
Creator	Yao, Ying Xu, Gang Zhang, Meng Wang, Kun Dong, Lei Li, Junhua Cheng, Yichun Ge, Shuwang Luo, Ran Wang, Zhixiang
Source	Elsevier; Medline; PMC
abstract	In December 2019, a coronavirus 2019 (COVID-19) disease outbreak occurred in Wuhan, Hubei Province, China, and rapidly spread to other areas worldwide. Although diffuse alveolar damage and acute respiratory failure were the main features, the involvement of other organs needs to be explored. Since information on kidney disease in patients with COVID-19 is limited, we determined the prevalence of acute kidney injury (AKI) in patients with COVID-19. Further, we evaluated the association between markers of abnormal kidney function and death in patients with COVID-19. This was a prospective cohort study of 701 patients with COVID-19 admitted in a tertiary teaching hospital that also encompassed three affiliates following this major outbreak in Wuhan in 2020 of whom 113 (16.1%) died in hospital. Median age of the patients was 63 years (interquartile range, 50-71), including 367 men and 334 women. On admission, 43.9% of patients had proteinuria and 26.7% had hematuria. The prevalence of elevated serum creatinine, elevated blood urea nitrogen and estimated glomerular filtration under 60 ml/min/1.73m2 were 14.4, 13.1 and 13.1%, respectively. During the study period, AKI occurred in 5.1% patients. Kaplan-Meier analysis demonstrated that patients with kidney disease had a significantly higher risk for in-hospital death. Cox proportional hazard regression confirmed that elevated baseline serum creatinine (hazard ratio: 2.10, 95% confidence interval: 1.36-3.26), elevated baseline blood urea nitrogen (3.97, 2.57-6.14), AKI stage 1 (1.90, 0.76-4.76), stage 2 (3.51, 1.49-8.26), stage 3 (4.38, 2.31-8.31), proteinuria 1+ (1.80, 0.81-4.00), 2+∼3+ (4.84, 2.00-11.70), and hematuria 1+ (2.99, 1.39-6.42), 2+∼3+ (5.56,2.58- 12.01) were independent risk factors for in-hospital death after adjusting for age, sex, disease severity, comorbidity and leukocyte count. Thus, our findings show the prevalence of kidney disease on admission and the development of AKI during hospitalization in patients with COVID-19 is high and is associated with in-hospital mortality. Hence, clinicians should increase their awareness of kidney disease in patients with severe COVID-19.
has issue date	2020-05-31(xsd:dateTime)
bibo:doi	10.1016/j.kint.2020.03.005
bibo:pmid	32247631
has license	els-covid
sha1sum (hex)	2f3489e0cfb08b40188631c9a0dfd20e2fa43633
schema:url	https://doi.org/10.1016/j.kint.2020.03.005
resource representing a document's title	Kidney disease is associated with in-hospital death of patients with COVID-19
has PubMed Central identifier	PMC7110296
has PubMed identifier	32247631
schema:publication	Kidney International
resource representing a document's body	covid:2f3489e0cfb08b40188631c9a0dfd20e2fa43633#body_text
is schema:about of	named entity 'patients' named entity 'lymphocyte' named entity 'Chinese National Health Commission' named entity 'COVID-19 disease' named entity 'COVID' named entity 'serum' named entity 'COVID-19' named entity 'COVID' named entity 'hypoxia' named entity 'COVID' named entity 'China' named entity 'virus' named entity 'kidney' named entity 'Epidemiology' named entity 'angiotensin converting enzyme 2' named entity 'nephrotoxic' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'ritonavir' named entity '95% CI' named entity 'AKI' named entity 'COVID-19' named entity 'COVID' named entity 'COVID-19' named entity 'coronavirus' named entity 'mmol/l' named entity 'erythrocyte sedimentation rate' named entity 'oseltamivir' named entity 'lymphocyte count' named entity 'clinical practice' named entity 'Wuhan' named entity 'regression analyses' named entity 'sample size' named entity 'nephrotoxins' named entity 'glucocorticoids' named entity 'COVID-19' named entity 'serum creatinine' named entity 'prognosis' named entity 'intensive care unit' named entity 'kidney disease' named entity 'coronavirus' named entity 'AKI' named entity 'respiratory illness' named entity 'AKI' named entity 'COVID' named entity 'clinical diagnosis' named entity 'upper respiratory tract infection' named entity 'creatine kinase' named entity 'polymerase chain reaction' named entity 'immune-mediated' named entity 'plasma' named entity 'ACE2' named entity 'Estimated glomerular filtration rate' named entity 'COVID' named entity 'AKI' named entity 'serum creatinine' named entity '1, 2' named entity 'procalcitonin' named entity 'serum creatinine' named entity 'glucocorticoids' named entity 'SARS' named entity 'radiographic' named entity 'diabetes' named entity 'lymphopenia' named entity 'clinical symptoms' named entity 'serum creatinine' named entity 'kidney' named entity 'glucocorticoids' named entity 'serum creatinine' named entity 'kidney disease' named entity 'kidney' named entity 'influenza A virus subtype H1N1' named entity 'creatine kinase'

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