About: Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies

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About: Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies
Creator	Kuzmin, Ivan Meslin, Francois Rupprecht, Charles
topic	covid:2f38b7690f9e7ab1069f6b9e28c103de5f6adb96#this
Source	Medline; PMC
abstract	Lyssaviruses are bullet-shaped, single-stranded, negative-sense RNA viruses and the causative agents of the ancient zoonosis rabies. Africa is the likely home to the ancestors of taxa residing within the Genus Lyssavirus, Family Rhabdoviridae. Diverse lyssaviruses are envisioned as co-evolving with bats, as the ultimate reservoirs, over seemingly millions of years. In terms of relative distribution, overt abundance, and resulting progeny, rabies virus is the most successful lyssavirus species today, but for unknown reasons. All mammals are believed to be susceptible to rabies virus infection. Besides reservoirs among the Chiroptera, meso-carnivores also serve as major historical hosts and are represented among the canids, raccoons, skunks, mongooses, and ferret badgers. Perpetuating as a disease of nature with the mammalian central nervous system as niche, host breadth alone precludes any candidacy for true eradication. Despite having the highest case fatality of any infectious disease and a burden in excess of or comparative to other major zoonoses, rabies remains neglected. Once illness appears, no treatment is proven to prevent death. Paradoxically, vaccines were developed more than a century ago, but the clear majority of human cases are unvaccinated. Tens of millions of people are exposed to suspect rabid animals and tens of thousands succumb annually, primarily children in developing countries, where canine rabies is enzootic. Rather than culling animal populations, one of the most cost-effective strategies to curbing human fatalities is the mass vaccination of dogs. Building on considerable progress to date, several complementary actions are needed in the near future, including a more harmonized approach to viral taxonomy, enhanced de-centralized laboratory-based surveillance, focal pathogen discovery and characterization, applied pathobiological research for therapeutics, improved estimates of canine populations at risk, actual production of required vaccines and related biologics, strategies to maximize prevention but minimize unnecessary human prophylaxis, and a long-term, realistic plan for sustained global program support to achieve success in disease control, prevention, and elimination.
has issue date	2017-02-23(xsd:dateTime)
bibo:doi	10.12688/f1000research.10416.1
bibo:pmid	28299201
has license	cc-by
sha1sum (hex)	2f38b7690f9e7ab1069f6b9e28c103de5f6adb96
schema:url	https://doi.org/10.12688/f1000research.10416.1
resource representing a document's title	Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies
has PubMed Central identifier	PMC5325067
has PubMed identifier	28299201
schema:publication	F1000Res
resource representing a document's body	covid:2f38b7690f9e7ab1069f6b9e28c103de5f6adb96#body_text
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