About: Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS

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About: Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS
Creator	Drosten, Christian Corman, Victor Felix, Jan
Source	Elsevier; Medline; PMC
abstract	Abstract In 2002/2003, a novel coronavirus (CoV) caused a pandemic, infecting more than 8000 people, of whom nearly 10% died. This virus, termed severe acute respiratory syndrome-CoV was linked to a zoonotic origin from rhinolophid bats in 2005. Since then, numerous studies have described novel bat CoVs, including close relatives of the newly emerging Middle East respiratory syndrome (MERS)-CoV. In this paper we discuss CoV genomic properties and compare different taxonomic approaches in light of the technical difficulties of obtaining full genomic sequences directly from bat specimens. We first present an overview of the available studies on bat CoVs, with details on their chiropteran hosts, then comparatively analyze the increase in bat CoV studies and novel genomic sequences obtained since the SARS pandemic. We then conduct a comprehensive phylogenetic analysis of the genera Alpha- and Betacoronavirus, to show that bats harbour more CoV diversity than other mammalian hosts and are widely represented in most, but not all parts of the tree of mammalian CoVs. We next discuss preliminary evidence for phylogenetic co-segregation of CoVs and bat hosts encompassing the Betacoronavirus clades b and d, with an emphasis on the sampling bias that exists among bat species and other mammals, then present examples of CoVs infecting different hosts on the one hand and viruses apparently confined to host genera on the other. We also demonstrate a geographic bias within available studies on bat CoVs, and identify a critical lack of information from biodiversity hotspots in Africa, Asia and Latin America. We then present evidence for a zoonotic origin of four of the six known human CoVs (HCoV), three of which likely involved bats, namely SARS-CoV, MERS-CoV and HCoV-229E; compare the available data on CoV pathogenesis in bats to that in other mammalian hosts; and discuss hypotheses on the putative insect origins of CoV ancestors. Finally, we suggest caution with conclusions on the zoonotic potential of bat viruses, based only on genomic sequence data, and emphasize the need to preserve these ecologically highly relevant animals. This paper forms part of a symposium in Antiviral Research on “from SARS to MERS: 10years of research on highly pathogenic human coronaviruses”.
has issue date	2014-01-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2013.10.013
bibo:pmid	24184128
has license	els-covid
sha1sum (hex)	2f3b636f92b36de3ed42606e3e5bf088b94516e0
schema:url	https://doi.org/10.1016/j.antiviral.2013.10.013
resource representing a document's title	Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS
has PubMed Central identifier	PMC7113851
has PubMed identifier	24184128
schema:publication	Antiviral Research
resource representing a document's body	covid:2f3b636f92b36de3ed42606e3e5bf088b94516e0#body_text
is schema:about of	named entity 'nucleocapsid' named entity 'biodiversity hotspots' named entity 'zoonotic transmission' named entity 'SARS-CoV' named entity 'PEDV' named entity 'SARS-CoV' named entity 'evolution' named entity 'evolution' named entity 'NL63' named entity 'infection' named entity 'predation' named entity 'bat' named entity 'phylogenetic' named entity 'reverse genetics' named entity 'evolution' named entity 'genotypes' named entity 'causative agent' named entity 'genomes' named entity 'Molossidae' named entity 'Elsevier' named entity 'genome' named entity 'Bat' named entity 'coronaviruses' named entity 'MERS-CoV' named entity 'Betacoronavirus 1' named entity 'MERS-CoV' named entity 'SARS' named entity 'viruses' named entity 'RdRp' named entity 'mouse hepatitis virus' named entity 'clade' named entity 'coronavirus' named entity 'betacoronavirus' named entity 'HKU5' named entity 'pandemics' named entity 'bat' named entity 'viruses' named entity 'Hilgenfeld' named entity 'Antiviral Research' named entity 'alphacoronaviruses' named entity 'viruses' named entity 'FIPV' named entity 'rodent' named entity 'HCoV-NL63' named entity 'intermediate hosts' named entity 'Thailand' named entity 'mammals' named entity 'MERS-CoV' named entity 'Eulipotyphla' named entity 'Africa' named entity 'HKU1' named entity 'Moes' named entity '229E' named entity 'mammals' named entity 'HCoV-OC43' named entity 'subfamily' named entity 'gene' named entity 'RNA viruses' named entity 'intermediate hosts' named entity 'TGEV' named entity 'influenza' named entity 'MERS-CoV' named entity 'viruses' named entity 'betacoronaviruses' named entity 'MERS' named entity 'Hypsugo savii' named entity 'ORF' named entity 'Recombination' named entity 'genetic distance' named entity 'metagenomic' named entity 'SARS-related coronaviruses' named entity 'RBD' named entity 'H1N1' named entity 'taxonomic' named entity 'molecule' named entity 'MERS-CoV' named entity 'phylogenetic position' named entity 'Asia' named entity 'TGEV'

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